Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis

NCT ID: NCT07056257

Last Updated: 2025-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-08

Study Completion Date

2025-03-07

Brief Summary

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This study aims to evaluate and compare the effect of combination therapy between diode laser and omega3 gel in the local drug delivery approach as an adjunct to scaling and root planning on the management of localized aggressive periodontitis clinically and immunologically.

Detailed Description

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Periodontitis is a disease of the periodontium occurring in an otherwise healthy adolescent, which is characterized by a rapid loss of alveolar bone about more than one tooth of the permanent dentition.

The laser approach is an efficient and atraumatic technique to enhance its use for periodontal treatment. Within the limits of scientific data, treatment with diode laser and SRP showed a higher effect than SRP or laser alone.

Omega3 Polyunsaturated fatty acids (PUFA) have well recognized anti-inflammatory properties. They decrease inflammation through multiple pathways.

Conditions

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Diode Laser Therapy Omega 3 Localized Aggressive Periodontitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group I

Thirteen sites \[scaling-root planning (SRP)\] were used as a control group.

Group Type ACTIVE_COMPARATOR

Scaling-root planning (SRP)

Intervention Type PROCEDURE

Thirteen sites \[scaling-root planning (SRP)\] were used as a control group.

Group II

Thirteen sites \[scaling-root planning (SRP)+ laser therapy with application of methyl cellulose gel at repeated times weekly for one month\].

Group Type EXPERIMENTAL

Scaling-root planning (SRP)+ laser therapy

Intervention Type PROCEDURE

Thirteen sites \[scaling-root planning (SRP)+ laser therapy with application of methyl cellulose gel at repeated times weekly for one month\].

Group III

Thirteen sites \[scaling-root planning (SRP) + omega 3 gel repeated time weekly for one month\].

Group Type EXPERIMENTAL

Scaling-root planning (SRP)+ omega 3 gel

Intervention Type PROCEDURE

Thirteen sites \[scaling-root planning (SRP) + omega 3 gel repeated time weekly for one month\].

Group IV

Thirteen sites \[combination therapy between scaling-root planning (SRP) + laser + omega 3 gel in repeated time weekly for one month\].

Group Type EXPERIMENTAL

Scaling-root planning (SRP)+ laser therapy+ omega 3 gel

Intervention Type PROCEDURE

Thirteen sites \[combination therapy between scaling-root planning (SRP) + laser + omega 3 gel in repeated time weekly for one month\].

Interventions

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Scaling-root planning (SRP)

Thirteen sites \[scaling-root planning (SRP)\] were used as a control group.

Intervention Type PROCEDURE

Scaling-root planning (SRP)+ laser therapy

Thirteen sites \[scaling-root planning (SRP)+ laser therapy with application of methyl cellulose gel at repeated times weekly for one month\].

Intervention Type PROCEDURE

Scaling-root planning (SRP)+ omega 3 gel

Thirteen sites \[scaling-root planning (SRP) + omega 3 gel repeated time weekly for one month\].

Intervention Type PROCEDURE

Scaling-root planning (SRP)+ laser therapy+ omega 3 gel

Thirteen sites \[combination therapy between scaling-root planning (SRP) + laser + omega 3 gel in repeated time weekly for one month\].

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with localized aggressive periodontitis.
* Patients must be medically free.
* Optimal compliance as evidenced by no missed treatment appointments and a positive attitude to maintain oral hygiene.
* Patients who are willing to participate in this study can enroll and complete it.

Exclusion Criteria

* Patients with generalized aggressive periodontitis. Patients are over 35 years old.
* Pregnancy.
* Patients had scaling and root planning or antibiotic therapy in the last 6 months.
* Patients with hypersensitivity to fish oil.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Dalia Mohammed Elsayed Ghannam

Dentist at ministry of health

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tanta University

Tanta, El-Gharbia, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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R-OMPDR-4-22-11

Identifier Type: -

Identifier Source: org_study_id

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