Clinical Assessment of Adjunctive Omega-3 Versus Vitamin D Daily Supplements on Active Periodontal Therapy With Stage II Grade B Periodontitis Patients
NCT ID: NCT06654063
Last Updated: 2025-12-12
Study Results
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Basic Information
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RECRUITING
NA
72 participants
INTERVENTIONAL
2025-04-01
2025-12-01
Brief Summary
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Detailed Description
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1. Clinical attachment loss (CAL)
2. Plaque index (PI)
3. Gingival index (GI)
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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non-surgical periodontal therapy (SRP)
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
non-surgical periodontal therapy (SRP)+ Omega-3
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA)
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Patients will start taking Omega-3 supplements on the day of SRP procedure.
non-surgical periodontal therapy (SRP)
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
non-surgical periodontal therapy (SRP)+ Vitamin D
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Serum vitamin D levels will be assessed at baseline and 6 weeks after intervention in all groups.
non-surgical periodontal therapy (SRP)+ Omega-3
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA)
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Patients will start taking Omega-3 supplements on the day of SRP procedure.
non-surgical periodontal therapy (SRP)+ Omega-3
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA)
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Patients will start taking Omega-3 supplements on the day of SRP procedure.
non-surgical periodontal therapy (SRP)
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
non-surgical periodontal therapy (SRP)+ Vitamin D
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Serum vitamin D levels will be assessed at baseline and 6 weeks after intervention in all groups.
non-surgical periodontal therapy (SRP)+ Vitamin D
* Patients will start taking Omega-3 supplements on the day of SRP procedure.
* Serum vitamin D levels will be assessed at baseline and 6 weeks after intervention in all groups.
non-surgical periodontal therapy (SRP)+ Omega-3
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA)
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Patients will start taking Omega-3 supplements on the day of SRP procedure.
non-surgical periodontal therapy (SRP)
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
non-surgical periodontal therapy (SRP)+ Vitamin D
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Serum vitamin D levels will be assessed at baseline and 6 weeks after intervention in all groups.
Interventions
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non-surgical periodontal therapy (SRP)+ Omega-3
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA)
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Patients will start taking Omega-3 supplements on the day of SRP procedure.
non-surgical periodontal therapy (SRP)
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
non-surgical periodontal therapy (SRP)+ Vitamin D
* The CAL PPD and mSBI will be measured for each patient and will be recorded at baseline and 6 weeks
* all patients will receive supragingival and sub-gingival plaque and calculus debridement (SRP) with an ultrasonic scaler (Various 350; NSK, Japan) and a manual universal curette (Gracey; Hu-Friday, Chicago, USA) where, conventional scaling and root planning (SRP) to the bottom of the pocket of 4 mm or more
* Subgingival saline irrigation will be performed adjunctively to Sub-gingival curettage.
* Serum vitamin D levels will be assessed at baseline and 6 weeks after intervention in all groups.
Eligibility Criteria
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Inclusion Criteria
* Patients aged \> 25 years
* Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease (Papapanou et al. 2017).
* Patients with interdental clinical attachment loss (CAL) of 3-4 mm
* No history of previous periodontal therapy.
* No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs.
* No previous periodontal surgery at involved sites.
* Good oral hygiene and good compliance with the plaque control instructions following initial therapy.
* Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months
* Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders
* Absence of oral mucosal inflammatory conditions such as aphthous ulcers or lichen planus.
Exclusion Criteria
* Smoking habits
* Pregnant and lactating mothers
* Patients who have been received periodontal surgery in the study area during the last 6 months.
25 Years
50 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Marwa Helal
Lecturer Periodontology and implantology
Locations
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Marwa Helal
Cairo, , Egypt
Countries
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Central Contacts
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Other Identifiers
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531024
Identifier Type: -
Identifier Source: org_study_id
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