Evaluation of iPRF With Vitamin C in StageII Grade A Periodontitis
NCT ID: NCT05129267
Last Updated: 2021-11-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
45 participants
INTERVENTIONAL
2021-10-03
2022-06-02
Brief Summary
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Detailed Description
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Group 1: Scaling and root planing alone using Gracey curettes and ultrasonic scalers.
Group 2: Scaling and root planing using Gracey curettes and ultrasonic scalers with local delivery of injectable PRF using an insulin syringe with the blunt needle inserted into the bottom of the periodontal pocket through a template to hold the locally delivered injectable PRF.
The intervention approach:
Scaling and root planing using Gracey curettes and ultrasonic scalers with local delivery of vitamin C (250 μM) and injectable PRF, using an insulin syringe with the blunt needle inserted into the bottom of the periodontal pocket through a template to hold the locally delivered vitamin C and injectable PRF for a longer time.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Group B
Scaling and Root Debridement + iPRF
Group B
Scaling and Root debridement + iPRF
Group C
Scaling and Root Debridement + iPRF +Vitamin C
Group C
Scaling and Root debridement + iPRF together with vitamin C
Group A
Scaling and Root Debridement
No interventions assigned to this group
Interventions
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Group B
Scaling and Root debridement + iPRF
Group C
Scaling and Root debridement + iPRF together with vitamin C
Eligibility Criteria
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Inclusion Criteria
2. Adult patients ˃ 18 years old.
3. Patients with Stage II Grade A periodontitis.
4. Patients accept 6-months follow-up period (cooperative patients).
5. Patients provide an informed consent.
Exclusion Criteria
2. Extensive restorations.
3. Periodontal therapy within the last 12 months.
4. Having surgical therapy or undergoing orthodontic treatment.
5. Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis.
6. The use of antibiotics or anti-inflammatory drugs 1 month prior to the procedure and till the end of 6 months of follow-up.
7. Smokers.
8. Pregnant females.
18 Years
ALL
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Mohamed Abdulhakim Mohamed Sherif
Principal investigator
Locations
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Faculty of Oral and Dental Medecine-CU
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Mohamed Ab Sherif, Master
Role: primary
References
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Sherif MA, Anter E, Graetz C, El-Sayed KF. Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2025 May 23;25(1):772. doi: 10.1186/s12903-025-06115-x.
Other Identifiers
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PER 3- 3- 2
Identifier Type: -
Identifier Source: org_study_id