25-Hydroxyvitamin D Levels in Patients With Periodontitis (Stage III)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

83 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-10

Study Completion Date

2022-05-10

Brief Summary

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Periodontitis; is an inflammatory disease of tissues characterized by bone destruction around the teeth. Vitamin D plays an important role in several inflammatory diseases by promoting the expression of inflammatory cytokines such as interleukin IL-1, IL-6, and IL-1β, which are directly related to periodontal attachment loss and bone demineralization. These facts suggest that vitamin D may be associated with periodontal disease. Many studies have been conducted on the relationships between serum 25-hydroxyvitamin D (25(OH)D) levels, periodontal disease, and tooth loss. However, as far as we know, there is no study on the relationship between periodontitis and free and bioavailable 25 (OH) vitamin D. In our study, over the age of 35; two groups will be formed, consisting of 40 healthy and 40 periodontitis individuals. Serum total 25 (OH) D level and vitamin D binding protein level will be analyzed by ELISA method, and bioavailable 25 (OH) D level will be calculated using total 25 (OH) D and vitamin D binding protein levels. The aim of this study; To evaluate the total, free and bioavailable 25 (OH) vitamin D levels of patients with periodontitis by comparing them with healthy controls, and to investigate whether bioavailable 25 (OH) D plays a role in the pathogenesis of periodontitis or can be a simple marker of disease activity in the light of these findings.

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Detailed Description

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Conditions

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Vitamin D Deficiency Periodontitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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Healthy

taking a blood sample

Intervention Type DIAGNOSTIC_TEST

blood collection for routine biochemical analysis

Periodontitis

taking a blood sample

Intervention Type DIAGNOSTIC_TEST

blood collection for routine biochemical analysis

Interventions

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taking a blood sample

blood collection for routine biochemical analysis

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Without systemic disease,
* Had a least 14 teeth

Exclusion Criteria

* Individuals with a history of systemic or topical oral antimicrobial therapy use in the last 3 months,
* Individuals with an allergy to any ingredient used in the study,
* Smokers,
* Pregnant or breastfeeding women,
* Using vitamin D,
* Individuals diagnosed with obesity

Minimum Eligible Age

35 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes