Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy
NCT ID: NCT07287540
Last Updated: 2025-12-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2025-11-22
2026-04-01
Brief Summary
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A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.
Detailed Description
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Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education
non surgical periodontal trearment
All participants will receive nonsurgical periodontal treatment
anti-inflammatory nutrition education
Participants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education
Q3-2: Only nonsurgical periodontal treatment
non surgical periodontal trearment
All participants will receive nonsurgical periodontal treatment
Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education
non surgical periodontal trearment
All participants will receive nonsurgical periodontal treatment
anti-inflammatory nutrition education
Participants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education
Q4-2: Only nonsurgical periodontal treatment
non surgical periodontal trearment
All participants will receive nonsurgical periodontal treatment
Interventions
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non surgical periodontal trearment
All participants will receive nonsurgical periodontal treatment
anti-inflammatory nutrition education
Participants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education
Eligibility Criteria
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Inclusion Criteria
* Not smoking
* Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
* Not being pregnant or lactating
* Not having received periodontal treatment in the last 6 months
* Having at least 20 teeth in the mouth
* Being diagnosed with periodontitis by the investigator
* Having a dietary inflammatory index \>0
Exclusion Criteria
* Smoking
* Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
* Being pregnant or lactating
* Having received periodontal treatment within the last 6 months
* Having fewer than 20 teeth in the mouth
* No periodontitis
20 Years
65 Years
ALL
No
Sponsors
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Recep Tayyip Erdogan University
OTHER
Recep Tayyip Erdogan University Training and Research Hospital
OTHER
Responsible Party
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Hatice Yemenoğlu
Doctor
Locations
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Recep Tayyip Erdoğan University
Rize, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Hatice Yemenoglu
Role: primary
Other Identifiers
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Recep TayyipErdoğan University
Identifier Type: -
Identifier Source: org_study_id