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Dietary Inflammatory Index and Periodontal Status in Obese Patients

NCT ID: NCT07287553

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-11-22

Study Completion Date

2026-03-21

Brief Summary

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In this study aimed to investigate the effect of nutrition on periodontal status in individuals diagnosed with obesity and without any other systemic disease, and to investigate the relationship between DII and periodontal disease risk. A total of 200 participants will be included in the study. Participants' overall daily Dietary Inflammatory Index (DII) scores will be calculated. The obtained scores will be divided into four groups, from low to high: Q1 (n=50), Q2 (n=50), Q3 (n=50), and Q4 (n=50). According to the DII, groups Q1 and Q2, which include lower scores, represent individuals on an anti-inflammatory diet, while groups Q3 and Q4, which include higher scores, represent individuals on a pro-inflammatory diet. Interleukin (IL)-1β, IL-10, total oxidant status (TOS), and total antioxidant status (TAS) were collected from gingival crevicular fluid (GCF) and serum samples. The levels of biomarkers such as malondialdehyde (MDA), glutathione (GSH), leptin, adiponectin, tumor necrosis factor (TNF)-α and C-reactive protein (CRP) from serum samples alone will be analyzed by ELISA method at the Recep Tayyip Erdoğan University Medical Biochemistry Laboratory.

Detailed Description

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Conditions

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Obesity

Keywords

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obesity periodontal status dietary inflammatory index

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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anti-inflammatory diet group 1

Individuals on an anti-inflammatory diet

Periodontal indices will be obtained

Intervention Type OTHER

Periodontal indices will be obtained from all participants

serum and crevicular fluid samples will be collected

Intervention Type OTHER

Serum and gingival crevicular fluid samples will be collected from all participants.

anti-inflammatory diet group 2

Individuals on an anti-inflammatory diet

Periodontal indices will be obtained

Intervention Type OTHER

Periodontal indices will be obtained from all participants

serum and crevicular fluid samples will be collected

Intervention Type OTHER

Serum and gingival crevicular fluid samples will be collected from all participants.

pro-inflammatory diet group 1

individuals on a pro-inflammatory diet

Periodontal indices will be obtained

Intervention Type OTHER

Periodontal indices will be obtained from all participants

serum and crevicular fluid samples will be collected

Intervention Type OTHER

Serum and gingival crevicular fluid samples will be collected from all participants.

pro-inflammatory diet group 2

individuals on a pro-inflammatory diet

Periodontal indices will be obtained

Intervention Type OTHER

Periodontal indices will be obtained from all participants

serum and crevicular fluid samples will be collected

Intervention Type OTHER

Serum and gingival crevicular fluid samples will be collected from all participants.

Interventions

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Periodontal indices will be obtained

Periodontal indices will be obtained from all participants

Intervention Type OTHER

serum and crevicular fluid samples will be collected

Serum and gingival crevicular fluid samples will be collected from all participants.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Being diagnosed with obesity,
* Not having any systemic conditions other than obesity (systemic diseases that may affect periodontal health, such as cardiovascular disease, chronic kidney disease, Type 1 diabetes, Type 2 diabetes, and hypertension (\>130/85 mmHg)),
* Being between the ages of 18 and 65,
* Not smoking or consuming alcohol,
* Not having used anti-inflammatory medications in the last 3 months, or antibiotics or systemic corticosteroids in the last 6 months,
* Not being pregnant or lactating,
* Not having received periodontal treatment in the last 6 months,
* Not having received nutritional advice in the last 3 months,
* Obesity diagnosis: BMI \> 30 kg/m2 or waist circumference: \> 100 cm for men and \> 90 cm for women.

Exclusion Criteria

* Non-obese
* Having any systemic disease other than obesity (such as cardiovascular disease, chronic kidney disease, Type 1 diabetes, Type 2 diabetes, and hypertension (\>130/85 mmHg) that may affect periodontal health)
* Being over 65 years old and under 18 years old
* Smoking and alcohol use
* Having used anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
* Being pregnant or lactating
* Having received periodontal treatment in the last 6 months
* Having received nutritional advice in the last 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Recep Tayyip Erdogan University Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hatice Yemenoğlu

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Recep Tayyip Erdoğan University

Rize, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Hatice Yemenoglu

Role: CONTACT

Phone: +905052977517

Email: [email protected]

Facility Contacts

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Hatice Yemenoglu

Role: primary

Other Identifiers

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RecepTayyip ErdoganUniversity

Identifier Type: -

Identifier Source: org_study_id