Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men
NCT ID: NCT02127346
Last Updated: 2015-10-05
Study Results
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Basic Information
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COMPLETED
200 participants
OBSERVATIONAL
2014-05-31
2015-10-31
Brief Summary
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Detailed Description
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Vitamin D and calcium are fundamental for bone mineralization and for the prevention of osteoporosis Severe vitamin D deficiency lead to mineralization defects but chronically low intake of vitamin D and calcium leads to bade calcium balance and bone loss, and it is reasonable to expect this effect to occur in alveolar bone as it does in other bones of the body. A study has showed a positive association between low bone mass or osteoporosis and alveolar bone loss and tooth loss.
Vitamin D serum concentrations might affect periodontal disease both through an effect on bone mineral density (BMD) and through immunomodulatory effects. Vitamin D is well established as being essential for bone growth and preservation. A potential anti-inflammatory effect of vitamin D is supported by an increasing amount of literature. The active metabolite of 25-hydroxyvitamin D, 1,25dihydroxyvitamin D, has been found to inhibit cytokine production and cell proliferation.
Low serum levels of vitamin D have been linked with a loss of periodontal attachment. Data from over 11,000 subjects were analyzed for serum vitamin D levels and attachment loss. In subjects less than 50 years of age, there was no significant association reported between vitamin D levels and attachment loss. In patients 50 years or older, serum vitamin D levels were inversely associated with attachment loss for men and women. It was concluded that the increased risk for periodontal disease might be attributable to low levels of vitamin D, which would reduce bone mineral density, or to an immunomodulatory effect.
In van der Putten et al study, based on the literature available to date, the association of vitamin D, and calcium deficiencies with periodontal disease in elderly people is essentially still unknown and not well researched. To produce conclusive evidence on the subject of this systematic literature review, longitudinal cohort studies and follow-up randomized controlled trials are needed
The aim of this study is to explore chronic periodontitis status and serum vitamin D and calcium concentrations in Syrian males and compare these figures with matched healthy volunteers with no periodontitis.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Chronic Periodontitis
1. Male patients
2. Patients are suffering from chronic periodontitis
3. Patients do not have any systemic diseases
4. Subjects should have 20 teeth at least
5. Age: 30 years or greater
No interventions assigned to this group
Healthy Volunteers
1. Males
2. Healthy with no systemic diseases or periodontitis
3. 30 years old at least
4. 20 teeth are present at least
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Patients are suffering from chronic periodontitis
3. Patients do no have systemic diseases
4. Patients should have 20 teeth at least
5. 30 year old at least
1. Male individuals
2. With no systemic diseases or periodontitis
3. 30 year old at least
4. 20 teeth at least for each participant
30 Years
50 Years
MALE
Yes
Sponsors
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Damascus University
OTHER
Responsible Party
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Principal Investigators
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Mohammad Alharissi, DDS MSc
Role: PRINCIPAL_INVESTIGATOR
PhD student, Department of Periodontics, University of Damascus Dental School, Damascus
Suleiman Dayoub, DDS MSc PhD
Role: STUDY_CHAIR
Associate Professor of Periodontics, Department of Periodontics, University of Damascus Dental School, Damascus
Rowaida Saymeh, DDS MSc PhD
Role: STUDY_DIRECTOR
Professor of Periodontics, Department of Periodontics, University of Damascus Dental School, Damascus
Locations
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Department of Periodontics, University of Damascus Dental School
Damascus, Rif-dimashq Governorate, Syria
Countries
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References
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Chapuy MC, Meunier PJ. [Calcium and vitamin D3, a prevention of femoral neck fractures in elderly women]. Presse Med. 1993 Apr 10;22(13):615-6. No abstract available. French.
Crowle AJ, Ross EJ, May MH. Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun. 1987 Dec;55(12):2945-50. doi: 10.1128/iai.55.12.2945-2950.1987.
Dennison DK, Van Dyke TE. The acute inflammatory response and the role of phagocytic cells in periodontal health and disease. Periodontol 2000. 1997 Jun;14:54-78. doi: 10.1111/j.1600-0757.1997.tb00192.x. No abstract available.
Jeffcoat M. The association between osteoporosis and oral bone loss. J Periodontol. 2005 Nov;76(11 Suppl):2125-32. doi: 10.1902/jop.2005.76.11-S.2125.
Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000. 2001;25:8-20. doi: 10.1034/j.1600-0757.2001.22250102.x. No abstract available.
Liu H, Komai-Koma M, Xu D, Liew FY. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7048-53. doi: 10.1073/pnas.0601554103. Epub 2006 Apr 21.
Ramanathan B, Davis EG, Ross CR, Blecha F. Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect. 2002 Mar;4(3):361-72. doi: 10.1016/s1286-4579(02)01549-6.
Other Identifiers
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UDDS-Perio-04-2014
Identifier Type: -
Identifier Source: org_study_id
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