Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-02

Study Completion Date

2015-11-26

Brief Summary

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To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.

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Detailed Description

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Seventy five participants were divided into 3 groups. The groups consisted of GROUP I- generalized severe chronic periodontitis, GROUP II- generalized moderate chronic periodontitis and GROUP III- systemically and periodontally healthy volunteers who served as control. The selected patients were then evaluated for periodontal parameters, lipid profile and Lp-PLA2.

Conditions

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Chronic Periodontitis (Disorder)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

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GROUP I

Estimation of serum lipid levels and Lp-PLA2 in generalized severe chronic periodontitis

serum lipid levels and Lp-PLA2

Intervention Type DIAGNOSTIC_TEST

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

GROUP II

Estimation of serum lipid levels and Lp-PLA2 in generalized moderate chronic periodontitis

serum lipid levels and Lp-PLA2

Intervention Type DIAGNOSTIC_TEST

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

GROUP III

Estimation of serum lipid levels and Lp-PLA2 in systemically and periodontally healthy controls

serum lipid levels and Lp-PLA2

Intervention Type DIAGNOSTIC_TEST

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

Interventions

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serum lipid levels and Lp-PLA2

Estimation of Total Cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, very low density lipoprotein and Lipoprotein associated lipophosphase A2 in chronic periodontitis

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Biological marker

Eligibility Criteria

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Inclusion Criteria

Group I:

1. Subjects with age ≥ 35 years.
2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) ≥ 5mm in more than 30% of sites.

Group II:

1. Subjects with age ≥ 35 years.
2. Presence of at least 24 teeth, with Clinical attachment loss (CAL) between 3-4 mm in more than 30% of sites.

Group III:

1. Subjects with age ≥ 35 years.
2. Healthy and intact periodontium

Exclusion Criteria

1. Presence of any systemic disease or conditions that could affect periodontal tissues.
2. History of periodontal treatment in past 6 months.
3. Smoking and alcoholism
4. Anomalies of blood and immune system
5. Systemic medication or antibiotic treatment for the previous 6 months.
6. Pregnant females.

Minimum Eligible Age

35 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes