Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-01

Study Completion Date

2020-12-01

Brief Summary

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Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease. The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR

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Detailed Description

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The study is done in order to assess the demographic variables such as age, height, weight and socio-economic status, BMI, personal habits, waist-hip ratio, lipid profile, use of medications, and family history of coronary artery disease in generalised chronic periodontitis subjects with and without coronary artery disease. To assess and compare the periodontal status of generalised chronic periodontitis subjects with and without coronary artery disease. To determine the expression of NLRP3 (rs4612666) and CARD8 gene (rs2043211) polymorphisms in subgingival tissue samples of generalised chronic gingivitis periodontitis subjects with and without coronary artery disease. To correlate the demographic variables and periodontal parameters and the expression of NLRP3 (rs4612666) and CARD8 (rs2043211) gene polymorphisms in generalised chronic periodontitis patients with coronary artery disease and compare them with systemically healthy chronic periodontitis patients

Conditions

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Periodontal Diseases Coronary Artery Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Periodontitis group

35 Generalized chronic periodontitis subjects without coronary heart diseases

No interventions assigned to this group

periodontitis with CAD group

35 Generalized chronic periodontitis subjects diagnosed with Coronary heart disease

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients willing to participate in the study
* Patients within the age group of 30-65 years ( male )
* Patients should have ≥ 20 remaining natural teeth
* No history of long term antibiotic use in the past 6 months
* For group I generalized chronic periodontitis patients with coronary heart disease
* For group II generalized chronic periodontitis patients without coronary heart disease

Exclusion Criteria

* Patients with systemic conditions such as type I, and type II diabetes mellitus, respiratory diseases, renal disease, liver disease, rheumatoid arthritis, allergy, advanced malignancies and hiv infection will be excluded from the present investigation.
* Patients on drugs such as corticosteroids, antibiotics within 3 months of investigation will be excluded.
* Current smokers, individuals who quit smoking less than 6 months ago.
* Patients who had undergone periodontal therapy within the previous 6 months

Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No