Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
133 participants
OBSERVATIONAL
2014-06-01
2017-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Control
Evaluation of serum and salivary NLRP3
Observation of serum and salivary NLRP3 levels
Evaluation of serum and salivary NLRP3 levels
Periodontitis
Evaluation of serum and salivary NLRP3
Observation of serum and salivary NLRP3 levels
Evaluation of serum and salivary NLRP3 levels
Diabetes
Evaluation of serum and salivary NLRP3
Observation of serum and salivary NLRP3 levels
Evaluation of serum and salivary NLRP3 levels
Periodontitis + diabetes
Evaluation of serum and salivary NLRP3
Observation of serum and salivary NLRP3 levels
Evaluation of serum and salivary NLRP3 levels
Interventions
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Observation of serum and salivary NLRP3 levels
Evaluation of serum and salivary NLRP3 levels
Eligibility Criteria
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Inclusion Criteria
* CP with a minimum of 40% of sites with a clinical attachment level (CAL)
≥2mm and probing depth (PD) ≥4mm;
* Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
* Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion Criteria
* Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
* Status of pregnancy or lactation
* Previous history of excessive drinking
* Allergy to local anaesthetic
* Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
35 Years
70 Years
ALL
Yes
Sponsors
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University of Messina
OTHER
Responsible Party
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Gaetano Isola, DDS, PhD
Researcher
Principal Investigators
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Giovanni Matarese
Role: STUDY_CHAIR
University of Messina
Locations
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University of Messina
Messina, , Italy
Countries
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Other Identifiers
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23-18
Identifier Type: -
Identifier Source: org_study_id
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