Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects

NCT ID: NCT02830113

Last Updated: 2016-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-12-31

Study Completion Date

2015-09-30

Brief Summary

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This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.

Detailed Description

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Subjects with chronic periodontitis will undergo non-surgical periodontal treatment (NSPT) consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution. Periodontal parameters (plaque index, gingival bleeding index, pocket depth, and clinical attachment loss), insulin sensitivity using KITT, glucose tolerance using oral glucose tolerance test and serum CRP level by immunoturbidimetry will be measured before and 3 months after the NSPT.

Conditions

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Periodontitis Prediabetes

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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non-surgical periodontal treatment

One session of non-surgical periodontal treatment consisting of a complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution.

Group Type EXPERIMENTAL

non-surgical periodontal treatment

Intervention Type PROCEDURE

One session of complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution

Interventions

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non-surgical periodontal treatment

One session of complete scaling, polishing, root planning, and the irrigation of periodontal pockets with a 10% povidone iodine solution

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Chronic periodontitis
* Non diabetic individual

Exclusion Criteria

* Known diabetes
* Periodontal treatment less than 6 months prior to inclusion
* Having less than 20 natural teeth
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Yaounde 1

OTHER

Sponsor Role collaborator

Yaounde Central Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Sobngwi Eugene

Professor of Endocrinology and Diabetes

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Eugene Sobngwi, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Yaoundé 1 and Yaoundé Central Hospital

References

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Nana Nana AR, Tsobgny Tsague NF, Lontchi-Yimagou E, Bengondo Messanga C, Tankeu A, Katte JC, Balti Vounsia E, Dehayem M, Sobngwi E. Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study). J Investig Med. 2021 Oct;69(7):1377-1381. doi: 10.1136/jim-2021-001831. Epub 2021 Jul 14.

Reference Type DERIVED
PMID: 34261767 (View on PubMed)

Other Identifiers

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CNO20155

Identifier Type: -

Identifier Source: org_study_id

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