Serum Hs-CRP in Periodontitis Patients With or Without Diabetes

NCT ID: NCT03908606

Last Updated: 2019-04-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-11

Study Completion Date

2019-01-02

Brief Summary

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the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy.

Detailed Description

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Periodontitis and diabetes are chronic disorders with a two-way correlation as they can both stimulate an inflammatory response with subsequent formation of inflammatory mediators and cytokines. C reactive protein is an inflammatory plasma marker having a role in the systemic reaction to inflammation. thus, our aim in the current study was to evaluate serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy. A total of 60 patients were enrolled in this study. ELISA was used for determination of hs- CRP. Non- surgical periodontal therapy was carried out for all periodontitis patients.

Conditions

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Periodontal Disease Diabetes Mellitus, Type 2

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Periodontitis patients with diabetes type 2

scaling and root planing was administered to all patients. Serum samples were collected before and after treatment to assess hs-CRP levels. Glycated hemoglobin was measured before and after treatment

Group Type EXPERIMENTAL

Scaling and root planing

Intervention Type PROCEDURE

Supra and subgingival scaling and root planing.

Periodontitis patients

scaling and root planing will be done to periodontitis patients. Serum samples were collected before and after treatment to assess hs-CRP levels.

Group Type EXPERIMENTAL

Scaling and root planing

Intervention Type PROCEDURE

Supra and subgingival scaling and root planing.

Healthy control group

We measured serum levels of hs-CRP in all healthy control subjects

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Scaling and root planing

Supra and subgingival scaling and root planing.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Diabetic patients type 2
2. Periodontitis patients

Exclusion Criteria

1. Smokers
2. Pregnant females
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Gihane Gharib Madkour

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gihane Madkour, Prof

Role: STUDY_DIRECTOR

Cairo University

Locations

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Cairo University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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1281976

Identifier Type: -

Identifier Source: org_study_id

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