Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients

NCT ID: NCT00399620

Last Updated: 2009-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Brief Summary

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Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided. Periodontal disease has been cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a family of proteins present in nervous endocrine and immune cells, released with catecholamines during stress situations. Chromogranin A (CGA) is the major member of this family.The aim of this study is to determine the level of CGA and its derived peptides in the gingival crevicular fluid (GCF) of health or diabetic patients with and without periodontitis.Then, we want to determine the antimicrobial activity of these peptides.

Detailed Description

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Conditions

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Periodontitis and Diabetitis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

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Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients from 20 to 80 years old
* A minimum of 10 teeth
* Healthy volunteers or diabetic patients with or without periodontitis

Exclusion Criteria

* a course of antibiotics
* a fungicidal therapy
* a corticotherapy
* a hormone therapy
* a pregnancy
* persons under guardianship
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Principal Investigators

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Martine Soell, MD

Role: STUDY_DIRECTOR

Hôpitaux Universitaires de Strasbourg

Locations

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Département de Parodontologie - Hôpital Civil

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Martine Soell, MD

Role: CONTACT

33 6 74 86 67 36

Facility Contacts

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Martine Soell, MD

Role: primary

33.6.74.86.67.36

Other Identifiers

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3739

Identifier Type: -

Identifier Source: org_study_id

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