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Endocan Biomarker Level in Gingival Crevicular Fluid in Periodontitis Patients With Type 2 Diabetes Mellitus

NCT ID: NCT05667051

Last Updated: 2022-12-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

42 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-05

Study Completion Date

2022-09-10

Brief Summary

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Aim of the current study was to evaluate Endocan biomarker level in gingival crevicular fluid of patients with stage 1 or 2 (mild to moderate) periodontitis with controlled type 2 diabetes mellitus (DM) and compare it to that in DM free periodontitis patients.

Detailed Description

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Conditions

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Periodontitis Diabetes Mellitus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Controlled type 2 diabetes mellitus

No interventions assigned to this group

Diabetes mellitus free patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Probing pocket depths (PPD) ≤ 5 mm.
* Clinical attachment level (CAL) ≤ 4 mm.
* Type 2 DM, for at least the past 3 years.
* HbA1c ≤ 7%.

Exclusion Criteria

* Uncontrolled Diabetes Mellitus.
* Systemic antibiotic or anti-inflammatory medication use in the previous 2 months.
* Non-surgical periodontal therapy in the previous 6 months.
* Surgical periodontal therapy in the previous 12 months.
* Use of calcium channel blockers, phenytoin, or cyclosporine.
* Pregnancy.
* Smokers
Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alexandria University

OTHER

Sponsor Role lead

Responsible Party

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Emad Ayad

MSc candidate, Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology Department, Faculty of Dentistry, Alexandria University

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Emad Ayyad, BDS

Role: PRINCIPAL_INVESTIGATOR

Faculty of Dentistry, Alexandria University, Egypt

Maha Abou Khadr, PhD

Role: STUDY_DIRECTOR

Faculty of Dentistry, Alexandria University, Egypt

Mona Ayyad, PhD

Role: STUDY_CHAIR

Faculty of Medicine, Alexandria University, Egypt

Gillan El-Kimary, PhD

Role: STUDY_CHAIR

Faculty of Dentistry, Alexandria University, Egypt

Locations

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Faculty of Dentistry, Alexandria University

Alexandria, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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#256

Identifier Type: -

Identifier Source: org_study_id