Possible Role of Gingival Crevicular Fluid Levels of Chemerin and Fibroblast Growth Factor 21 as Biomarkers of Periodontal Disease in Diabetic and Non-diabetic Patients
NCT ID: NCT04012983
Last Updated: 2019-07-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2018-03-01
2018-09-01
Brief Summary
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The study will be conducted on three groups; group (A) include fifteen controlled T2 DM patients suffering from periodontitis, group (B) include fifteen patients suffering from periodontitis alone, and group C) include fifteen periodontally and medically healthy individuals. GCF samples will be collected from all participants for assessment of Chemerin and FGF 21. Samples will be analysed using ELISA technique.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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diabetic patients with periodontitis
gingival crevicular fluid level
gingival crevicular fluid collection
periodontitis patients
gingival crevicular fluid level
gingival crevicular fluid collection
healthy control
gingival crevicular fluid level
gingival crevicular fluid collection
Interventions
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gingival crevicular fluid level
gingival crevicular fluid collection
Eligibility Criteria
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Inclusion Criteria
* a minimum of 20 natural teeth.
* Type 2DM patients exhibiting HbA1c 6-8% and FPG ≥126 mg/dL for more than one year who did not complain of any systemic diseases other than t2DM
* periodontitis patients with moderate to severe periodontitis having gingival index GI ≥ 1, probing depth PD ≥ 5, and clinical attachment level CAL ≥ 4 mm, and bone loss affecting \> 30% of existing teeth on clinical/radiographic examination
Exclusion Criteria
* systemic diseases which may affect the biomarkers levels and the periodontal conditions.
* Exposure to steroid therapies, radiation/immune-suppressive therapies.
* Allergic reaction to any kind of drug.
* Smoking over the past 5 years.
* Periapical pathologies.
* Exposure to mechanical forces as a result of occlusion/ orthodontics.
* History of periodontal or drug therapies within the previous 6 months.
35 Years
60 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Eman Mohamed Amr
Associate Professor
Locations
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Faculty of Dentistry
Cairo, , Egypt
Countries
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Other Identifiers
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chemerin and FGF21
Identifier Type: -
Identifier Source: org_study_id
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