Gut Microbial Changes After Periodontal Treatment

NCT ID: NCT04982302

Last Updated: 2023-05-18

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 94 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-05-01
• Study Completion Date: 2023-02-01

Brief Summary

Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients. The long-term swallowing of high doses of periodontal pathogenic microorganisms could induce a dysbiosis of the intestinal microbiota, favouring the establishment of an 'inflamed' microbiome in terms of composition and/or function. The present project is aimed at a better understanding of the etiopathogenetic correlation between periodontitis and intestinal dysbiosis, and aims to explore the hypothesis that non-surgical periodontal treatment may reduce bacterial alpha diversity in stool samples. Fifty patients affected by stage III-IV periodontitis will be recruited, and treated by means of full-mouth scaling and root planing. Salivary and stool samples, together with a complete periodontal charting and a food diary will be collected and compared at baseline and 3 months after treatment. Age, gender and BMI-matched healthy individuals will be recruited as controls.

Conditions

Periodontitis; Dysbiosis; Intestinal Disease

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Non-surgical periodontal treatment NSPT

Subgingival instrumentation with ultrasonic devices and curettes of all periodontal pockets in 2 or 4 appointments

Non-surgical periodontal treatment

Intervention Type: PROCEDURE

Subgingival instrumentation with ultrasonic devices and curettes of all periodontal pockets

Interventions

Non-surgical periodontal treatment

Subgingival instrumentation with ultrasonic devices and curettes of all periodontal pockets

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• periodontitis Stage III or IV
• BMI between 20 and 29 kg/m2
• free diet
• presence of at least 20 teeth

Exclusion Criteria

• systemic diseases (including diabetes, thyroid, liver, or kidney diseases)
• dietary allergies
• use of antibiotics or probiotics during the previous 30 days
• pregnancy or breast feeding

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Turin, Italy

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CIR Dental School

Turin, , Italy

Countries

Italy

Other Identifiers

Perio-gut connection

Identifier Type: -

Identifier Source: org_study_id