Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
NCT ID: NCT04580355
Last Updated: 2021-05-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
30 participants
INTERVENTIONAL
2021-07-31
2022-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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FMUD + Placebos
One session of full-mouth ultrasonic debridement (FMUD) with a time limit of 45 minutes plus placebo administration prescribed on the day of treatment, every 8 hours for 7 days.
One-Stage Full Mouth Debridement
Periodontal debridement
Amoxicillin Placebo
Administration of Placebo on the day of treatment tid for 7 days.
Metronidazole Placebo
Administration of Placebo on the day of treatment tid for 7 days.
FMUD + AM
One session of full-mouth ultrasonic debridement (FMUD) with a time limit of 45 minutes plus 500 mg Amoxicillin and 250 mg Metronidazole (AM) prescribed on the day of treatment, every 8 hours for 7 days.
One-Stage Full Mouth Debridement
Periodontal debridement
Amoxicillin 500mg
Administration of Amoxicillin 500mg prescribed on the day of treatment tid for 7 days.
Metronidazole 400mg
Administration of Metronidazole 400mg prescribed on the day of treatment tid for 7 days.
Interventions
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One-Stage Full Mouth Debridement
Periodontal debridement
Amoxicillin 500mg
Administration of Amoxicillin 500mg prescribed on the day of treatment tid for 7 days.
Metronidazole 400mg
Administration of Metronidazole 400mg prescribed on the day of treatment tid for 7 days.
Amoxicillin Placebo
Administration of Placebo on the day of treatment tid for 7 days.
Metronidazole Placebo
Administration of Placebo on the day of treatment tid for 7 days.
Eligibility Criteria
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Inclusion Criteria
* Presence of at least 20 teeth
* Good general health
Exclusion Criteria
* Were suffering from any other systemic diseases (e.g., cardiovascular, diabetes)
* Received antimicrobials in the previous 6 months
* Received a course of periodontal treatment within the last 6 months
* Were taking long-term anti-inflammatory drugs
* Smoking habits
18 Years
35 Years
ALL
No
Sponsors
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University of Campinas, Brazil
OTHER
Responsible Party
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Renato Casarin
Professor of Periodontics in Piracicaba Dental School-FOP/UNICAMP
Locations
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University of Campinas, UNICAMP
Piracicaba, São Paulo, Brazil
Countries
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Facility Contacts
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Other Identifiers
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23626219.7.0000.5418
Identifier Type: -
Identifier Source: org_study_id
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