Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
326 participants
OBSERVATIONAL
2015-02-15
2020-02-25
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Control
Healthy patients
Observation of suPAR plasma and salivary levels
Evaluation of suPAR plasma level and correlation of plasma suPAR levels with periodontal and cardiovascular disease
Periodontitis
Patients with periodontitis
Observation of suPAR plasma and salivary levels
Evaluation of suPAR plasma level and correlation of plasma suPAR levels with periodontal and cardiovascular disease
Cardiovascular disease
Patients with cardiovascular disease
Observation of suPAR plasma and salivary levels
Evaluation of suPAR plasma level and correlation of plasma suPAR levels with periodontal and cardiovascular disease
Periodontitis + cardiovascular disease
Patients with Periodontitis + cardiovascular disease
Observation of suPAR plasma and salivary levels
Evaluation of suPAR plasma level and correlation of plasma suPAR levels with periodontal and cardiovascular disease
Interventions
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Observation of suPAR plasma and salivary levels
Evaluation of suPAR plasma level and correlation of plasma suPAR levels with periodontal and cardiovascular disease
Eligibility Criteria
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Inclusion Criteria
* CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
* Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
* Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion Criteria
* Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
* Status of pregnancy or lactation
* Previous history of excessive drinking
* Allergy to local anaesthetic
* Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
40 Years
65 Years
ALL
Yes
Sponsors
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University of Catania
OTHER
University of Messina
OTHER
Responsible Party
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Gaetano Isola, DDS, PhD
Researcher
Principal Investigators
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Giovanni Matarese
Role: STUDY_CHAIR
University of Messina
Locations
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University of Messina
Messina, , Italy
Countries
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Other Identifiers
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11-18-18
Identifier Type: -
Identifier Source: org_study_id
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