Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
NCT ID: NCT04178590
Last Updated: 2020-07-13
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE4
32 participants
INTERVENTIONAL
2019-10-02
2020-07-09
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis
NCT06920849
Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis
NCT07029035
Injectable Platelet Rich Fibrin in Periodontal Treatment
NCT06814418
Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy
NCT04070729
The Effectiveness of Root Planing and Injectable Platelet-Rich Fibrin in Smoking Patients With Periodontitis
NCT07049549
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Thirty patients with chronic periodontitis who had at least two sites with perriodontal pocket depth (PPD) ≥ 4 mm on contralateral side will be involved in the study. Using a split-mouth design, patients will be treated with SRP + I-PRF -(test group) or SRP only-(control group). Gingival crevicular fluid (GCF) and subgingival plaque will be collected with paper points (DentsplyMaillefer, Tulsa, Oklahoma, USA) at baseline and 1, 3 and 6 months after the treatment. The presence and concentrations of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi) and Tannerella forsythia(Tf) will be analyzed by real-time polymerase chain reaction (qPCR). Periodontal parameters, including bleeding on probing (BOP), probing pocket depth (PPD) and the clinical attachment level (CAL), will be recorded on both sides, as well as concentration of TNF-alpha (tumor necrosis factor alpha), ALP(alkaline phosphatase) and MMP-8 (matrix-metalloproteinase-8).
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
SRP + Injectable Platelet-Rich Fibrin
Scaling and root planing in conjunction with Injectable Platelet-Rich Fibrin
SRP + Injectable Platelet-Rich Fibrin
Injectable Platelet-Rich Fibrin application as adjunct to scaling and root planing
SRP + placebo
Scaling and root planing in conjunction with saline
SRP + placebo
Saline application during scaling and root planing
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
SRP + Injectable Platelet-Rich Fibrin
Injectable Platelet-Rich Fibrin application as adjunct to scaling and root planing
SRP + placebo
Saline application during scaling and root planing
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* A minimum of 2 teeth in each quadrant with a probing depth (PD) ≥5 mm;
* Bleeding on probing (BOP) had to be at ≥40% tooth sites;
* No involvement of furcation;
* Good general health.
Exclusion Criteria
* Having surgical therapy;
* Use of antibiotics over the last 6 months;
* Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis;
* Pregnancy or nursing;
* Current and former smokers.
20 Years
65 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Belgrade
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Natasa Nikolic Jakoba
Associate professor, DDS, MSc, PhD
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Mila Vuckovic, Dr.
Role: PRINCIPAL_INVESTIGATOR
Assistant Lecturer
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Department of Periodontology and Oral medicine, School of Dental Medicine, University of Belgrade
Belgrade, , Serbia
Countries
Review the countries where the study has at least one active or historical site.
Provided Documents
Download supplemental materials such as informed consent forms, study protocols, or participant manuals.
Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
UBelgrade 783/2
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.