Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies
NCT ID: NCT07165054
Last Updated: 2026-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
51 participants
OBSERVATIONAL
2025-04-10
2025-12-01
Brief Summary
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Detailed Description
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Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.
Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Patients diagnosed with endarterectomy
atheroma plaque
Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
Dental plaque
Subgingival plaque samples will be collected from patients before the endarterectomy procedure.
Interventions
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atheroma plaque
Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
Dental plaque
Subgingival plaque samples will be collected from patients before the endarterectomy procedure.
Eligibility Criteria
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Inclusion Criteria
* Not receiving chemotherapy
* Not having received this treatment before
Exclusion Criteria
* Patients with severe heart disease
25 Years
90 Years
ALL
No
Sponsors
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Istanbul Saglik Bilimleri University
OTHER
Responsible Party
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Ayşe Toraman
associate professor
Locations
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Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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1
Identifier Type: -
Identifier Source: org_study_id
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