Macrophage Markers in Periodontal and Peri-implant Health and Disease
NCT ID: NCT05242354
Last Updated: 2023-05-18
Study Results
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View full resultsBasic Information
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COMPLETED
36 participants
OBSERVATIONAL
2021-03-01
2021-12-31
Brief Summary
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Detailed Description
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Healthy peri-implant samples are obtained from submerged implants during exposure surgery. Healthy gingiva samples are obtained from individuals receiving crown lengthening, gingivectomy or tooth extraction as excess tissue during the corresponding treatment. Samples from peri-implantitis and periodontitis (pocket depth ≥6 mm, bleeding on probing+) are obtained during initial periodontal treatment / debridement procedure with a single stroke at the pocket wall.
The samples will be grinded and ultrasonicated. Western blotting will be used for determination of CD80, CD163 and CD206 in biopsy specimens. ImageJ will be used for intensity analysis of the bands.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Periodontal health
Periodontally healthy individuals (2017 Classification of Periodontal Diseases and Conditions) who are planned to receive crown lengthening / gingivectomy of tooth extraction involving at least one site with pocket depth ≤3mm, bleeding on probing -
No interventions assigned to this group
Peri-implant health
Periodontally healthy individuals (2017 Classification of Periodontal Diseases and Conditions) with at least one partially-exposed dental implant with no bone loss prior to the prosthetic rehabilitation
No interventions assigned to this group
Periodontitis
Generalized Stage III Grade C periodontitis patients (2017 Classification of Periodontal Diseases and Conditions) having at least one site with pocket depth ≥6mm, bleeding on probing +
No interventions assigned to this group
Peri-implantitis
Individuals with at least one implant site with radiographic bone loss, pocket depth ≥6mm and bleeding on probing +
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* diagnosed with peri-implantitis
* periodontally healthy individuals with dental implants in the primary healing period
* periodontally healthy individuals who are in need of crown lengthening / gingivectomy or extraction
Exclusion Criteria
* smoking / former smokers
* regular medicine intake
* antibiotic or anti-inflammatory medicine intake in the last 3 months
* pregnancy or lactation
18 Years
ALL
Yes
Sponsors
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University of Turku
OTHER
Biruni University
OTHER
Responsible Party
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Mustafa YILMAZ
Asst Prof
Locations
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Biruni University
Istanbul, , Turkey (Türkiye)
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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Peri-implant macrophage
Identifier Type: -
Identifier Source: org_study_id
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