Evaluation of the Effects of Immune Cells on Periodontal Healing
NCT ID: NCT04792372
Last Updated: 2022-08-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
52 participants
INTERVENTIONAL
2021-02-23
2022-06-30
Brief Summary
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42 individuals will be included in the study. Granulation tissue samples will be collected from two separate deep pockets of each individual, initially. At the same session, full-mouth scaling and root debridement will be conducted. Saliva, subgingival biofilm and gingival crevicular fluid (GCF) samples will also be collected, initially, and at the 2nd, 6th, 12th and 24th weeks. At the same appointments, periodontal parameters will be recorded. When the clinical procedures are concluded, the samples will be sent to Turku University with dry ice. Tissue and GCF concentrations of related cytokines will be analyzed with Luminex. The density of macrophage types will be defined by immunoblot analysis of related markers. Macrophage subpopulations in tissues will be specified by proteomics. Likewise, quantities of periodontal pathogens will be evaluated with DNA isolation and next generation sequencing.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
SCREENING
NONE
Study Groups
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Periodontitis patients
Single-group receiving periodontal treatment. The data will be evaluated according to the healing potential of individuals in the group and also site-specifically.
Initial periodontal treatment
Conventional periodontal treatment (scaling and root debridement) will be conducted
Interventions
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Initial periodontal treatment
Conventional periodontal treatment (scaling and root debridement) will be conducted
Eligibility Criteria
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Inclusion Criteria
* having at least two pockets ≥ 6 mm
* systemic healthy
Exclusion Criteria
* received antibiotic or antiinflammatory drugs in the last 6 months
* pregnant or in lactation
18 Years
ALL
No
Sponsors
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The Scientific and Technological Research Council of Turkey
OTHER
University of Turku
OTHER
Biruni University
OTHER
Responsible Party
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Mustafa YILMAZ
Asst Prof
Principal Investigators
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Mustafa YILMAZ
Role: PRINCIPAL_INVESTIGATOR
Biruni University
Locations
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Biruni University
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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TheMacPer
Identifier Type: -
Identifier Source: org_study_id
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