Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2011-04-30
2013-04-30
Brief Summary
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Detailed Description
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Thirty chronic periodontitis patients were randomized into 2 groups. As adjunctive to MPT, Group 1 consumed 2×108 CFU/day of Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt while Group 2 natural yoghurt once daily for 28 days. Subgingival plaque samples were obtained from 2 periodontal sites with probing pocket depth (PPD) of 4≤PPD\<7 mm via paper-points at baseline, 28th day, 3rd month. Samples were cultured to evaluate total viable count (TVC), the proportions of obligate anaerobes (OA) and Bifidobacterium species (B) (TVC%). The full-mouth recorded clinical parameters were plaque index, gingival index, PPD, bleeding on probing, and clinical attachment level.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Natural yoghurt
SRP+nature yogurt (Danone® yogurt, Luleburgaz, Türkiye)
probiotic or natural yoghurt
Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt
SRP
Scalling and root planing
Probiotic yoghurt
SRP+probiotic containing yogurt (Danone Activia® Plain, Luleburgaz, Türkiye)
probiotic or natural yoghurt
Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt
SRP
Scalling and root planing
Interventions
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probiotic or natural yoghurt
Bifidobacterium animalis subsp. lactis DN-173010 containing probiotic yoghurt
SRP
Scalling and root planing
Eligibility Criteria
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Inclusion Criteria
* the presence of at least 2 teeth with one approximal site with a probing pocket depth (PPD) of 4≤SD\<7 mm (5-7 mm) and a GI of ≥2 mm in each quadrant,
* previously untreated periodontitis, systemically healthy
Exclusion Criteria
* Antibiotics and anti-inflammatory drugs within 3 months before the study
* Untreated caries lesions or local retention factors
* Allergic reactions to lactose or fermented milk products
* Previous probiotic supplements in diet
* Smoking
* Pregnancy
18 Years
ALL
Yes
Sponsors
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Marmara University
OTHER
Responsible Party
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Principal Investigators
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Bahar Kuru, Prof. Dr.
Role: STUDY_DIRECTOR
Marmara University, Faculty of Dentistry, Department of Periodontology
Hafize Öztürk Özener, Dr.
Role: PRINCIPAL_INVESTIGATOR
Marmara University, Faculty of Dentistry, Department of Periodontology
Locations
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Marmara University
Istanbul, Maltepe, Turkey (Türkiye)
Countries
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Other Identifiers
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MAR-2011-03-30-24
Identifier Type: -
Identifier Source: org_study_id
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