Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
51 participants
INTERVENTIONAL
2011-11-30
2012-05-31
Brief Summary
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Fifty-one periodontally healthy individuals were given standard oral hygiene instructions and randomly divided into two groups. The test group subjects (n=26) consumed probiotic yoghurt containing Bifidobacterium animalis subsp. lactis and the control subjects (n=25) natural yoghurt for 28 days. Following yoghurt consumption, mechanical plaque control was interrupted for the next 5 days in both groups. Gingival crevicular fluid (GCF) samples and clinical data (consisted of plaque and gingival indices, probing depth, bleeding on probing) were collected at baseline, after 28 and 33 days. Interleukin-1β levels were determined in GCF by ELISA.
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Detailed Description
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Fifty-one periodontally healthy individuals were given standard oral hygiene instructions and randomly divided into two groups. The test group subjects (n=26) consumed probiotic yoghurt containing Bifidobacterium animalis subsp. lactis and the control subjects (n=25) natural yoghurt for 28 days. Following yoghurt consumption, mechanical plaque control was interrupted for the next 5 days in both groups. Gingival crevicular fluid (GCF) samples and clinical data (consisted of plaque and gingival indices, probing depth, bleeding on probing) were collected at baseline, after 28 and 33 days. Interleukin-1β levels were determined in GCF by ELISA.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Probiotic Yoghurt
Probiotic yoghurt consumption
Probiotic Yoghurt
Probiotic yoghurt consumption
Natural Yoghurt
Natural yoghurt consumption
Natural Yoghurt
Natural yoghurt consumption
Interventions
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Probiotic Yoghurt
Probiotic yoghurt consumption
Natural Yoghurt
Natural yoghurt consumption
Eligibility Criteria
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Inclusion Criteria
* Gingival Index ≤ 1
* No probing depth (Probing depth \> 3 mm)
* No approximal attachment loss \> 2 mm
* Non smokers
Exclusion Criteria
* Antibiotics and anti-inflammatory drugs within 3 months before the study
* Untreated caries lesions or local retention factors
* Mouth-breathing
* Allergies
* Previous probiotic supplements in diet
16 Years
26 Years
ALL
Yes
Sponsors
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Marmara University
OTHER
Responsible Party
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Principal Investigators
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Tuğçe Yalnızoğlu, PhD
Role: PRINCIPAL_INVESTIGATOR
Marmara University, Faculty of Dentistry, Department of Periodontology
Bahar Kuru, Prof Dr
Role: STUDY_DIRECTOR
Marmara University, Faculty of Dentistry, Department of Periodontology
Locations
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Marmara University, Faculty of Dentistry, Department of Periodontology
Istanbul, Sisli/Nisantasi, Turkey (Türkiye)
Countries
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Other Identifiers
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MAR-2011-10-11/14
Identifier Type: -
Identifier Source: org_study_id
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