Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals
NCT ID: NCT02423304
Last Updated: 2015-04-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2015-05-31
2016-06-30
Brief Summary
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Detailed Description
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* 50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study.
* An informed consent will be obtained from patients who wish to participate in the study.
* Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959)
* After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms.
* Subjects will be selected according to the study criteria and divided into two groups (50 each).
1. Test group
2. Control group
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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test
50 periodontitis patients
• Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959) blood samples collected from all patients serum separated and evaluated for77A/G AND 11A/12A associated gene polymorphism of Matrix Metallo Proteinase( MMP)-13 in all the patients. studies showing that there is co relation of these genes with increase inflammation.
blood samples collected from all patients
blood samples collected from brachial pluxes
control
50 periodontally healthy individuals blood samples collected from all patients serum separated and evaluated for77A/G AND 11A/12A associated gene polymorphism of Matrix Metallo Proteinase (MMP)-13 in all the patients
blood samples collected from all patients
blood samples collected from brachial pluxes
Interventions
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blood samples collected from all patients
blood samples collected from brachial pluxes
Eligibility Criteria
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Inclusion Criteria
2. Subjects aged between 30-55 years
* Control group Systemically and periodontally healthy individuals of same age group
Exclusion Criteria
2. Presence of any systemic diseases.
3. Oral diseases other than Periodontitis
4. With a previous history of periodontal treatment in the past 6 months and subjects under any medications.
5. Family history of any diagnosed genetic disorders.
30 Years
55 Years
ALL
Yes
Sponsors
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Research Institute for Genetic and Human Therapy
OTHER
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
OTHER
Responsible Party
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J.surya prasanna
dr.M.Divya Aiswairya
References
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Pirhan D, Atilla G, Emingil G, Tervahartiala T, Sorsa T, Berdeli A. MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy. J Clin Periodontol. 2009 Jun;36(6):474-81. doi: 10.1111/j.1600-051X.2009.01399.x. Epub 2009 Apr 22.
Uitto VJ, Airola K, Vaalamo M, Johansson N, Putnins EE, Firth JD, Salonen J, Lopez-Otin C, Saarialho-Kere U, Kahari VM. Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation. Am J Pathol. 1998 Jun;152(6):1489-99.
Kiili M, Cox SW, Chen HY, Wahlgren J, Maisi P, Eley BM, Salo T, Sorsa T. Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue. J Clin Periodontol. 2002 Mar;29(3):224-32. doi: 10.1034/j.1600-051x.2002.290308.x.
Hernandez Rios M, Sorsa T, Obregon F, Tervahartiala T, Valenzuela MA, Pozo P, Dutzan N, Lesaffre E, Molas M, Gamonal J. Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. J Clin Periodontol. 2009 Dec;36(12):1011-7. doi: 10.1111/j.1600-051X.2009.01488.x.
Other Identifiers
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Divya Aiswairya thesis
Identifier Type: -
Identifier Source: org_study_id
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