A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2014-11-30

Brief Summary

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Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

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Detailed Description

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Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin).

Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures.

Bone loss is a common feature shared between periodontal disease and osteoporosis.

Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.

Conditions

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Generalized Chronic Periodontitis Osteoporosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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CTR Gene in Osteoporosis and Periodontitis

Patients aged between 35 - 60 yrs with Osteoporosis (BMD\>-2.5) and Chronic Periodontitis (\>3mm Pocket Probing Depth)

CTR Gene

Intervention Type GENETIC

2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism

Interventions

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CTR Gene

2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism

Intervention Type GENETIC

Other Intervention Names

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Calcitonin Gene, Hypocalcaemic agent

Eligibility Criteria

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Inclusion Criteria

* Male and Female
* Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study

Exclusion Criteria

* Patients who are Systemically compromised and under medications such as steroids.
* Patients who smoke.Pregnant and lactating mothers are excluded from the study

Minimum Eligible Age

35 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes