Evaluation of Bone Metabolism Biomarkers in Periodontal Diseases
NCT ID: NCT05702892
Last Updated: 2023-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2020-11-05
2021-11-05
Brief Summary
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Detailed Description
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Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20 with periodontal healthy (S), were included in the study. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment level and probing pocket depth) and saliva samples were obtained from the individuals. Bone metabolism biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by enzyme-linked immunosorbent assay (ELISA).
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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periodontitis
ELISA
ELISA(enzyme-linked immunosorbent assay)
gingivitis
ELISA
ELISA(enzyme-linked immunosorbent assay)
periodontal healthy
ELISA
ELISA(enzyme-linked immunosorbent assay)
Interventions
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ELISA
ELISA(enzyme-linked immunosorbent assay)
Eligibility Criteria
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Inclusion Criteria
* not having any systemic disease that may affect periodontal status
* not smoking and alcohol use
* volunteer to participate in the study
Exclusion Criteria
* resulting from orthodontics and occlusion extreme forces, including mechanical forces;
* chronic high-dose steroid therapy;
* radiation or immunosuppressive therapy;
* pregnancy;
* breastfeeding;
* allergy or sensitivity to any medication.
* Periodontal therapy or drug therapy for at least 6 months of study participants
18 Years
65 Years
ALL
Yes
Sponsors
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Necmettin Erbakan University
OTHER
Responsible Party
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Ummuhan Tekin Atay
master in science
Locations
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Necmettin Erbakan University
Konya, , Turkey (Türkiye)
Countries
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Other Identifiers
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Ummuhan.tekinatay
Identifier Type: -
Identifier Source: org_study_id
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