Inflammatory Stress and Periodontal Tissue Destruction

NCT ID: NCT06092853

Last Updated: 2023-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-06

Study Completion Date

2023-06-06

Brief Summary

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Metabolic syndrome and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin resistance, they may be comorbid. The aim of this study was to evaluate the effect of interleukin-20 (IL-20) on periodontal destruction in individuals with metabolic syndrome while considering the relationship between metabolic syndrome and periodontitis.

This study included a total of 80 individuals who were systemically and periodontally healthy (CG, n=20), were systemically healthy and had periodontitis (PG, n=20), had metabolic syndrome and were periodontally healthy (MG, n=20), or had both metabolic syndrome and periodontitis (MPG, n=20). Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses.

Detailed Description

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Conditions

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Oxidative Stress Inflammation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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systemically and periodontally healthy (CG)

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses.

Gingival crevicular fluid (GCF) and serum samples

Intervention Type OTHER

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

systemically healthy and periodontitis (PG)

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Gingival crevicular fluid (GCF) and serum samples

Intervention Type OTHER

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Metabolic syndrome and periodontally healthy (MG)

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Gingival crevicular fluid (GCF) and serum samples

Intervention Type OTHER

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Metabolic syndrome and periodontitis (MPG)

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Gingival crevicular fluid (GCF) and serum samples

Intervention Type OTHER

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Interventions

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Gingival crevicular fluid (GCF) and serum samples

Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* all participants were required to have at least 20 teeth and be between the ages of 20 and 65 years

Exclusion Criteria

* Smokers, patients who had used antibiotics or anti-inflammatory and antioxidant drugs in the last 6 months, patients who were pregnant or lactating, those who had cancer or autoimmune diseases, and those who had undergone any periodontal treatment in the last 6 months
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Recep Tayyip Erdogan University

OTHER

Sponsor Role collaborator

Recep Tayyip Erdogan University Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hatice Yemenoğlu

assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Recep Tayyip Erdogan University

Rize, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Senkal R, Yemenoglu H, Kose O, Karakas SM, Yilmaz A, Akyildiz K, Beder M, Bostan SA. The role of interleukin-20 on inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis. BMC Oral Health. 2024 Nov 22;24(1):1423. doi: 10.1186/s12903-024-05224-3.

Reference Type DERIVED
PMID: 39578819 (View on PubMed)

Other Identifiers

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RecepTayyipErdoganUniversity

Identifier Type: OTHER

Identifier Source: secondary_id

Recep Tayyip ErdoganUniversity

Identifier Type: -

Identifier Source: org_study_id

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