Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2020-09-23
2021-03-03
Brief Summary
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Detailed Description
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Interleukine -1β ( IL-1β ) levels are associated with periodontal destruction in the pathogenesis of periodontal disease. Cytokines such as Interleukine-10 (IL-10) and transforming growth factor- β (TGF-β) have been reported to decrease periodontal disease progression rate.
Gingival crevicular fluid shows the cellular response in the periodontium. The most important host-related ingredients are inflammatory markers, including cytokines, enzymes, and interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in the diagnosis of oral pathologies.
Meteorin- like (Metrnl) is a protein that plays a role in natural and acquired immune-related functions and inflammatory responses, and expressed in barrier tissues (skin and mucosa) as well as various macrophage populations, from dendritic cells and some granulocytes. Metrnl has proven to be an inflammatory-related immunoregulatory cytokine and shown to play a role in the pathogenesis of human inflammatory diseases. Metrnl, which is highly expressed from the oral mucosa to the esophagus, may play a role in the onset of periodontitis and an effective marker in preventing the progression of destruction. We think that Metrnl plays an important role in periodontitis, an inflammatory disease. The aim of this study is to compare the Metrnl, IL-1β, and IL-10 levels of healthy and periodontitis individuals
Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Healthy
Individuals with Periodontally Healthy
Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
Gingivitis
Individuals with Gingival Inflammation
Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
Periodontitis
Individuals with Periodontitis
Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
Interventions
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Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* individuals who does not have a disease under treatment,
* individuals without regular systemic medication
Exclusion Criteria
* receiving periodontal treatment in the last 6 months
* pregnancy
* menopausal or menstrual period
18 Years
70 Years
ALL
Yes
Sponsors
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Istanbul Saglik Bilimleri University
OTHER
Responsible Party
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Ebru SAĞLAM
Principal Investigator,Health Sciences University, Dentistry Faculty
Principal Investigators
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Ayşe Toraman, Dr.
Role: STUDY_CHAIR
Saglik Bilimleri Universitesi
Serhat Köseoğlu, assoc prof
Role: STUDY_CHAIR
Saglik Bilimleri Universitesi
Mehmet Sağlam, assoc prof
Role: STUDY_CHAIR
Izmir Katip Celebi University
Levent Savran, PhD
Role: STUDY_CHAIR
Izmir Katip Celebi University
Ebru Sağlam, Dr
Role: PRINCIPAL_INVESTIGATOR
Saglik Bilimleri Universitesi
Locations
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Ebru Sağlam
Istanbul, Eyalet/Yerleşke, Turkey (Türkiye)
Countries
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Other Identifiers
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Sağlık Bilimleri Üniversitesi
Identifier Type: -
Identifier Source: org_study_id
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