Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes
NCT ID: NCT04891627
Last Updated: 2023-01-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
76 participants
OBSERVATIONAL
2021-01-06
2021-05-04
Brief Summary
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Detailed Description
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1. Inclusion criteria for H groups: Individuals with clinically healthy gingiva, no attachment and bone loss, and less than 10% bleeding on probing were included.
2. Inclusion criteria for periodontitis groups: Systemically healthy individuals with interdental CAL ≥ 5 mm and PPD ≥ 6 mm were included.
3. Inclusion criteria for periodontitis with diabetes groups: Type 2 diabetes patients with interdental CAL ≥ 5 mm, PPD ≥ 6 mm, and HbA1c ≥ 6.5% were included.
The plaque index (PI), gingival index (GI), presence of bleeding on probing (BOP), PD, and clinical AL were used for clinical periodontal assessments. All assessments were done with a manual probe. GCF samples were obtained and analyzed using an enzyme-linked immunosorbent assay.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Healthy control groups
individuals with clinically healthy gingiva BOP score less than 10% and PD≤3mm
Gingival crevicular fluid
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Periodontitis group
interdental AL ≥5 mm
Gingival crevicular fluid
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Periodontitis with diabetes group
HbA1c ≥6.5%
Gingival crevicular fluid
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Interventions
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Gingival crevicular fluid
GCF samples were collected in the morning hours 24-48 hours after clinical periodontal measurement.
Eligibility Criteria
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Inclusion Criteria
* have diabetes .
Exclusion Criteria
* smokers;
* pregnant
* those using drugs;
20 Years
65 Years
ALL
Yes
Sponsors
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Uşak University
OTHER
Responsible Party
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Principal Investigators
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ahu dikilitas
Role: PRINCIPAL_INVESTIGATOR
University of Usak
Locations
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University of Usak
Uşak, , Turkey (Türkiye)
Countries
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References
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Dikilitas A, Karaaslan F, Evirgen S, Ertugrul AS. Gingival crevicular fluid CSF-1 and IL-34 levels in patients with stage III grade C periodontitis and uncontrolled type 2 diabetes mellitus. J Periodontal Implant Sci. 2022 Dec;52(6):455-465. doi: 10.5051/jpis.2106260313. Epub 2022 Apr 12.
Other Identifiers
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UsakU8
Identifier Type: -
Identifier Source: org_study_id
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