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Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients

NCT ID: NCT03345745

Last Updated: 2017-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

54 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-01

Study Completion Date

2017-09-01

Brief Summary

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Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before and after non-surgical periodontal treatments in the patients with periodontal diseases.

A total of 54 subjects were divided in to three groups; periodontally healthy (n: 18), gingivitis (n: 18), chronic periodontitis (n: 18). Clinical periodontal parameters, salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments. Salivary Hs-CRP, Fetuin-A and S100A12 levels were assayed by ELISA.

Detailed Description

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Conditions

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Periodontal Inflammation

Keywords

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Fetuin-A S100A12 C-Reactive Protein Chronic Periodontitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Periodontally healthy subjects

Salivary samples

salivary samples

Intervention Type DIAGNOSTIC_TEST

Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments

Chronic periodontitis patients

Salivary samples

salivary samples

Intervention Type DIAGNOSTIC_TEST

Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments

Gingivitis patients

Salivary samples

salivary samples

Intervention Type DIAGNOSTIC_TEST

Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments

Interventions

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salivary samples

Salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

never-smokers no history of systemic disease no patients had been under periodontal therapy and medicine for at least 6 months before the study no pregnancy or lactation no alcohol or antioxidant vitamin consumption.

Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ordu University

OTHER

Sponsor Role lead

Responsible Party

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Cankat Kara

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ordu University

Ordu, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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OrduUniversityDentistry

Identifier Type: -

Identifier Source: org_study_id