(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis
NCT ID: NCT04850768
Last Updated: 2021-04-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
75 participants
OBSERVATIONAL
2021-04-16
2021-09-20
Brief Summary
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Detailed Description
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Interleukine -1β ( IL-1β ) levels are associated with periodontal destruction in the pathogenesis of periodontal disease. Interleukine-10 (IL-10) has been reported to decrease periodontal disease progression rate.
Gingival crevicular fluid shows the cellular response in the periodontium. The most important host-related ingredients are inflammatory markers, including cytokines, enzymes, and interleukins. Saliva analysis is used in the diagnosis of systemic conditions as well as in the diagnosis of oral pathologies.
Both NLRC4 and NLRP3 inflammasomes have been shown to play an important role in the induction of interleukin-1β secretion. Periodontitis is induced by a complex microbial biofilm containing multiple Gram-positive and Gram-negative bacteria (including flagellate microorganisms) capable of activating a large number of NLRs. It has been said that proinflammatory cytokines released in the microenvironment of periodontitis can increase the expression of NLRC4 inflammasome genes. Evidence on the role of inflammasomes in periodontal disease is still very poor. The aim of this study is to compare the NLRC4, IL-1β and IL-10 levels of healthy and periodontitis individuals.
Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Periodontitis
Individuals with Periodontitis
Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.
Gingivitis
Individuals with Gingival Inflammation
Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.
Healthy
Individuals with Periodontally Healthy
Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.
Interventions
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Saliva
individuals' saliva samples will be collected and transferred to eppendorf tubes.
Until biochemical analysis is carried out will be stored in -80ºC.
gingival crevicular fluid
GCF samples of individuals will be collected by paper strips and transferred to eppendorf tubes.Until biochemical analysis is carried out will be stored in -80ºC.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
70 Years
ALL
Yes
Sponsors
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Saglik Bilimleri Universitesi
OTHER
Responsible Party
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Ayse Toraman
Dr
Principal Investigators
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Ayşe Toraman, Dr
Role: PRINCIPAL_INVESTIGATOR
Saglik Bilimleri Universitesi
Ebru Sağlam, Dr
Role: STUDY_CHAIR
Saglik Bilimleri Universitesi
Serhat Köseoğlu, assoc prof
Role: STUDY_CHAIR
Saglik Bilimleri Universitesi
Mehmet Sağlam, assoc prof
Role: STUDY_CHAIR
Izmir Katip Celebi University
Levent Savran, PhD
Role: STUDY_CHAIR
Izmir Katip Celebi University
Locations
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Saglik Bilimleri Universitesi
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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Other Identifiers
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21-29
Identifier Type: -
Identifier Source: org_study_id
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