Association of Apical Periodontitis With Chronic Kidney Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

210 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-01

Study Completion Date

2022-12-31

Brief Summary

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This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.

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Detailed Description

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105 CKD patients (35 early (EG), 35pre-dialysis (PDG) and 35 hemodialysis (HDG)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . Inflammatory (hsCRP and ferritin) and nutritional (urea and creatinine) markers were estimated and eGFR was calculated for the study population. Logistic regression was used to determine the possible association between CKD and AP in study population and Linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (EB) in experimental group.

Conditions

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Chronic Kidney Diseases Periapical Lesions

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Group-A CKD patients

Prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis and change in PAI score, eGFR \& Systemic markers will be checked

levels of CKD markers, Oral health status, apical periodontitis

Intervention Type BIOLOGICAL

To observe levels of CKD markers :Levels of serum keratinise ,urea, eGFR, and assessment of Oral health status, apical periodontitis

Group-B Healthy individuals

Prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis and change in PAI score, eGFR \& Systemic markers will be checked

systemic inflammatory marker, Oral health status, apical periodontitis

Intervention Type BIOLOGICAL

estimation of hs-CRP levels, and assessment of Oral health status, apical periodontitis

Interventions

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levels of CKD markers, Oral health status, apical periodontitis

To observe levels of CKD markers :Levels of serum keratinise ,urea, eGFR, and assessment of Oral health status, apical periodontitis

Intervention Type BIOLOGICAL

systemic inflammatory marker, Oral health status, apical periodontitis

estimation of hs-CRP levels, and assessment of Oral health status, apical periodontitis

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Known patient of CKD Stages 1,2,3,4 \& 5 with estimated glomerular filtration rate \[eGFR; MDRD\] with mature permanent teeth.
* \> 18 years
* \> 8 natural teeth.
* Complete medical \& dental history including panoramic radiographs of maxilla \& mandible

Exclusion Criteria

* Patients having systemic disorders other than CKD (eg HIV, Diabetes mellitus, Coronary heart disease, history of secondary hyperparathyroidism).
* Pregnancy, lactation \& contraceptives.
* Systemic conditions that contra indicates dental treatment.
* Use of antibiotics \& anti-inflammatory in last 3 months
* Need for antibiotic prophylaxis.
* Hepatitis C and B virus.
* Patients on steroids.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes