Response to Periodontal Therapy in a Chronic Kidney Disease Population

NCT ID: NCT03525457

Last Updated: 2018-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-06

Study Completion Date

2019-12-31

Brief Summary

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This study will evaluate periodontal and systemic parameters of a cohort of chronic kidney disease (stage 5) patients, before and three months after non-surgical periodontal treatment. It does not consider a control group.

Detailed Description

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Dental biofilm is a source of inflammation and infection of periodontal tissues. In the last 20 years the interaction between periodontal infections and systemic conditions has been largely studied, suggesting that the inflammation caused in the periodontal tissues could cause a response in other parts of the body.

Recent studies suggest that there could be an association between periodontal disease and chronic kidney disease.

Conditions

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Chronic Kidney Disease Stage 5 Periodontal Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Experimental

Non surgical periodontal therapy

Group Type EXPERIMENTAL

Non Surgical Periodontal Therapy

Intervention Type PROCEDURE

Non Surgical Periodontal Therapy in 2 to 3 sessions

Interventions

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Non Surgical Periodontal Therapy

Non Surgical Periodontal Therapy in 2 to 3 sessions

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Chronic kidney disease patients in Stage 5 (candidates to renal transplant)

Exclusion Criteria

* Younger than 18 year old.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pontificia Universidad Catolica de Chile

OTHER

Sponsor Role lead

Responsible Party

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Maité Souyet

DDS, MsC

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maite C Souyet, MsC

Role: PRINCIPAL_INVESTIGATOR

Pontificia Universidad Catolica de Chile

Locations

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Clínica Odontológica Docente UC

Santiago, Santiago Metropolitan, Chile

Site Status RECRUITING

Countries

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Chile

Central Contacts

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Maite C Souyet, MsC

Role: CONTACT

+56978786186

Patricio F Smith, PhD

Role: CONTACT

Facility Contacts

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Maite C Souyet, MsC

Role: primary

+56878786186

References

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Almeida S, Figueredo CM, Lemos C, Bregman R, Fischer RG. Periodontal treatment in patients with chronic kidney disease: a pilot study. J Periodontal Res. 2017 Apr;52(2):262-267. doi: 10.1111/jre.12390. Epub 2016 May 2.

Reference Type BACKGROUND
PMID: 27135778 (View on PubMed)

Graziani F, Cei S, La Ferla F, Vano M, Gabriele M, Tonetti M. Effects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: an exploratory trial. J Clin Periodontol. 2010 Jul;37(7):638-43. doi: 10.1111/j.1600-051X.2010.01578.x. Epub 2010 May 25.

Reference Type BACKGROUND
PMID: 20500539 (View on PubMed)

Chambrone L, Foz AM, Guglielmetti MR, Pannuti CM, Artese HP, Feres M, Romito GA. Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. J Clin Periodontol. 2013 May;40(5):443-56. doi: 10.1111/jcpe.12067. Epub 2013 Feb 21.

Reference Type BACKGROUND
PMID: 23432795 (View on PubMed)

Limeres J, Garcez JF, Marinho JS, Loureiro A, Diniz M, Diz P. Early tooth loss in end-stage renal disease patients on haemodialysis. Oral Dis. 2016 Sep;22(6):530-5. doi: 10.1111/odi.12486. Epub 2016 May 27.

Reference Type BACKGROUND
PMID: 27038430 (View on PubMed)

Other Identifiers

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180104004

Identifier Type: -

Identifier Source: org_study_id

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