The Effect of Periodontal Disease Treatment in Patients With Kidney Disease
NCT ID: NCT03648723
Last Updated: 2018-08-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
43 participants
OBSERVATIONAL
2016-01-10
2017-05-10
Brief Summary
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Detailed Description
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In the lights of these informations, the purpose of the present study was to compare the effects of non-surgical periodontal therapy on patients undergoing continous ambulatory peritoneal dialysis(CAPD) due to diabetic nephropathy and non-diabetic. Forty three participants ( 22 Diabetic Nephropathy(DN) group , 21 Non-Diabetic Nephropathy(N-DN) group) were included and divided into the two group; DN group and N-DN group, in the present study.
The following clinical parameters were evaluated at baseline and the end of the study: Plaque index ; Gingival index ; pocket depth (PD) measurements; bleeding on probing (BOP)-percentage of BOP (+) sites; gingival recession (GR)-from the cement-enamel junction to the gingival margin; and clinical attachment level (CAL)-the sum of PD and GR measurements. The Decay-Missing-Filling Index (DMFT) was recorded. Clinical examinations were repeated 6 months following periodontal treatment. All clinical measurements were taken from the mid-buccal and mid-lingual sites and the buccal aspects of the interproximal contact area for the mesial and distal sites of each tooth to the nearest 0.5 mm using a 15 mm periodontal probe at baseline and the 6th months after treatment. All periodontal clinical examinations were performed by one calibrated examiner (FOT). At baseline and 6 months after treatment, fasting venous blood samples were collected from the antecubital fossa by an experienced nurse. Blood samples for TNF- α, IL-6 and PTX-3 were centrifuged, and separated serum and plasma samples were stored at -80◦C until analysis. TNF-α , IL-6 , and PTX-3 serum levels were determined using a commercial solid-phase enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's instructions. Periodontal treatments were performed 2 hours after the patients had their breakfast following the blood sampling. Standard oral hygiene instructions were given to all groups, including interdental plaque control (interdental brushes) and brushing of the dorsum of the tongue twice a day. Oral hygiene control and re-instructions were provided during all visits. After local infiltration, full-mouth scaling and root planning (FM-SRP) was performed by the same investigator with standard periodontal curettes
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Diabetic nephropathy
Diabetic nephropathy is defined by macroalbuminuria that is, a urinary albumin excretion of more than 300 mg in a 24-hour collection or macroalbuminuria and abnormal renal function as represented by an abnormality in serum creatinine, or glomerular filtration rate(GFR)
No interventions assigned to this group
Non-diabetic nephropathy
This group consisted of diagnosis with nephropathy without diabetes mellitus.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* ≥15 natural teeth
* needed to be \>30 years old
Exclusion Criteria
* pregnancy or lactation
* periodontal therapy within 6 months prior to the study
* past or current smoking and alcohol consumption
31 Years
65 Years
No
Sponsors
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TC Erciyes University
OTHER
Responsible Party
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Zekeriya Tasdemir
Principal investigator
Principal Investigators
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Zekeriya Taşdemir
Role: PRINCIPAL_INVESTIGATOR
TC Erciyes University
Other Identifiers
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Ztasdemir
Identifier Type: -
Identifier Source: org_study_id
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