Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease

NCT ID: NCT02848378

Last Updated: 2016-07-28

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 75 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-05-31
• Study Completion Date: 2015-04-30

Brief Summary

This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.

Detailed Description

Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.

Advanced oxidation protein product is identified as a new marker of protein oxidation.

Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.

Conditions

Inflammation; Periodontal Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Chronic periodontitis group

Subjects who have moderate to severe alveolar bone loss and clinical attachment level (CAL) ≥5 mm and probing depth (PD) ≥6mm in multiple sites of all four quadrants of the mouth but with no evidence of rapid progression

No interventions assigned to this group

Gingivitis group

Subjects who show gingival inflammation that is based on the presence of bleeding on probing (BOP) at \>50% of sites in the whole mouth, no clinical and radiographic signs of periodontitis

No interventions assigned to this group

Periodontally healthy group

Subjects who have no sites with PD \>3mm and CAL \>0 mm, a BOP score of \<15% at the examination and no alveolar bone loss.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Clinical diagnosis of chronic periodontitis and gingivitis

Exclusion Criteria

• Systemic illnesses
• Any medications known to affect the periodontium
• Pregnancy and lactation

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 66 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Kırıkkale University

OTHER

Sponsor Role: lead

Responsible Party

Meltem Karsiyaka Hendek

Corresponding author, Clinical Research

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

2014/17

Identifier Type: -

Identifier Source: org_study_id