Fractalkine-CX3CR1 Axis in Periodontal Therapy

NCT ID: NCT07307144

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-15

Study Completion Date

2023-12-10

Brief Summary

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This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.

Detailed Description

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Thirty stage 3 periodontitis, thirty gingivitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; gingivitis and periodontitis patients underwent non-surgical periodontal treatment, and GCF samples were collected at baseline and at 1 and 3 months after treatment. CX3CL1 and CX3CR1 were determined by ELISA.

Conditions

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Periodontitis Gingivitis Inflammation Biomarkers

Keywords

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periodontitis gingivitis gingival crevicular fluid

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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stage 3 periodontitis

GCF samples were collected at baseline and at 1 and 3 months after treatment from periodontitis patients.

Group Type ACTIVE_COMPARATOR

Non-surgical periodontal treatment

Intervention Type OTHER

Scaling and root planing, oral hygiene education and motivation.

Gingivitis

GCF samples were collected at baseline and at 1 and 3 months after treatment from gingivitis patients.

Group Type ACTIVE_COMPARATOR

Non-surgical periodontal treatment

Intervention Type OTHER

Scaling and root planing, oral hygiene education and motivation.

Periodontally healthy controls

GCF samples were collected from periodontally healthy controls at baseline for once.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Non-surgical periodontal treatment

Scaling and root planing, oral hygiene education and motivation.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. 25-50 years of age
2. having at least 20 natural teeth, excluding third molars
3. having no systemic disease
4. non-smokers
5. criteria for healthy control group: BOP \< 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction
6. criteria for stage 3 periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Exclusion Criteria

1. having any systemic diseases,
2. smoking
3. current pregnancy or lactation
4. a history of periodontal treatment in the past 6 months
5. using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.
Minimum Eligible Age

25 Years

Maximum Eligible Age

47 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Giresun University

OTHER

Sponsor Role lead

Responsible Party

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Zeynep Pınar Yucel

Assoc. Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Giresun University

Giresun, Turkey, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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SAĞ-BAP-A-240222-47

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

OMU KAEK 2022/85

Identifier Type: -

Identifier Source: org_study_id