Estimation of Pentraxin3 and PGingivalis Levels in Patients With Knee Joint and Gum Diseases

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-28

Study Completion Date

2015-12-31

Brief Summary

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Periodontitis and Rhematoid arthritis are chronic inflammatory diseases which share common risk factors The purpose of this study is to determine if Pentraxin 3 and Porphyromonas Gingivalis levels play an important role in the progression of both the diseases.

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Detailed Description

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Periodontal disease progression might play a significant role in the severity and outcome of systemic diseases like rheumatoid arthritis. Pentraxin3 is a newly discovered inflammatory biomarker. It is a member of acute phase proteins and it has been observed from previous studies that plasma pentraxin3 levels have increased with increasing severity of cardiac and renal problems.

Porphyromonas gingivalis proteinase is responsible for the epitope development in RF-Fc region These proteinases are important virulence factors which lead to degradation of host tissue. Porphyromonas gingivalis is also a key periodonto pathogen. Thus the aim of this study is to compare the plasma pentraxin3 and p.gingivalis levels in patients with periodontitis and rheumatoid arthritis.

Conditions

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Rheumatoid Arthritis Chronic Periodontitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Arthritis with Periodontitis

Patients aged between 30-65 years with 6 positive diagnostic criteria for Rhematoid Arthritis. Patients should have Clinical attachment loss \>6mm, and Probing pocket depth\>5mm in more than 6 teeth to satisfy criteria for periodontitis.

5ml of blood to be collected from each patient, centrifuged and plasma extracted used for estimation of Pentraxin3(Quantikine ELISA) Pooled plaque sample taken,DNA extracted by PCR for estimation of P.Gingivalis levels.

Estimation of Pentraxin3

Intervention Type OTHER

5ml of blood to be collected from each subject, centrifuged, to separate the plasma for estimation of Pentraxin3 (Quantikine ELISA)

Estimation of P.Gingivalis levels

Intervention Type GENETIC

Pooled plaque sample will be collected and sent for DNA Extraction by PCR for assessment of levels of PGingivalis

Periodontitis group

Patients aged between 30-65 years with Periodontal findings being presence of atleast 20 teeth in the mouth .More than 6 teeth with Clinical attachment loss \>6mm and Probing pocket depth\>5mm to satisfy criteria for periodontitis. 5ml of blood to be collected from each patient, centrifuged and plasma extracted used for estimation of Pentraxin3(Quantikine ELISA).

Pooled plaque sample taken,DNA extracted by PCR for estimation of P.Gingivalis levels..

Estimation of Pentraxin3

Intervention Type OTHER

5ml of blood to be collected from each subject, centrifuged, to separate the plasma for estimation of Pentraxin3 (Quantikine ELISA)

Estimation of P.Gingivalis levels

Intervention Type GENETIC

Pooled plaque sample will be collected and sent for DNA Extraction by PCR for assessment of levels of PGingivalis

Healthy Subjects

Subjects aged between 30-65 years with no systemic diseases and periodontitis. 5ml of blood to be collected from each patient, centrifuged and plasma extracted used for estimation of Pentraxin3(Quantikine ELISA).

Pooled plaque sample taken,DNA extracted by PCR for estimation of P.Gingivalis levels..

Estimation of Pentraxin3

Intervention Type OTHER

5ml of blood to be collected from each subject, centrifuged, to separate the plasma for estimation of Pentraxin3 (Quantikine ELISA)

Estimation of P.Gingivalis levels

Intervention Type GENETIC

Pooled plaque sample will be collected and sent for DNA Extraction by PCR for assessment of levels of PGingivalis

Interventions

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