Evaluation of Neopterin Levels in Pre and Post-menopausal Women With Periodontitis Following Non Surgical Therapy

NCT ID: NCT02357745

Last Updated: 2015-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-28

Study Completion Date

2015-05-31

Brief Summary

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Neopterin has been identified as a marker of cellular immune system activation. It is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin concentration increases with increasing severity of periodontal disease in diverse body fluids like Urine, Saliva and Plasma. Hence Neopterin can be considered as an important inflammatory marker in periodontal disease as well as other systemic diseases.

Detailed Description

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At baseline - plasma, urine and saliva samples were collected and analysed for neopterin levels from the pre and post-menopausal women with periodontitis . Followed by scaling and root planing done in both the groups. After 3 months again these 3 samples were collected and analysed for post treatment neopterin levels

Conditions

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Periodontitis

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Pre-menopausal with periodontitis

non surgical periodontal therapy ( scaling and root planing)

Non surgical periodontal therapy

Intervention Type PROCEDURE

scaling and root planing

Post-menopausal with periodontitis

non surgical periodontal therapy ( scaling and root planing)

Non surgical periodontal therapy

Intervention Type PROCEDURE

scaling and root planing

Interventions

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Non surgical periodontal therapy

scaling and root planing

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* moderate to chronic periodontitis
* non-smokers
* minimum 15 natural teeth present

Exclusion Criteria

* patients on long term steroid medication
* with gross oral pathology or tumors
* undergoing hormone replacement therapy
* not undergone periodontal therapy in past 6 months
* under medication in past 6 months
* systemic disorders and drugs which influence the periodontium
Minimum Eligible Age

40 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

OTHER

Sponsor Role lead

Responsible Party

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DR.CH.SUMADHURA

SUMADHURA

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Bakhtadze MG, Margvelashvili VV, Kamkamidze GK. [Interferon-gamma and neopterin in blood serum of patients with chronic periodontitis after autograft operations]. Georgian Med News. 2006 Mar;(132):30-3. Russian.

Reference Type BACKGROUND
PMID: 16636374 (View on PubMed)

Arjunkumar R, Sudhakar U, Jayakumar P, Arunachalam L, Suresh S, Virupapuram P. Comparative analysis of gingival crevicular fluid neopterin levels in health and periodontal disease: a biochemical study. Indian J Dent Res. 2013 Sep-Oct;24(5):582-6. doi: 10.4103/0970-9290.123376.

Reference Type RESULT
PMID: 24355959 (View on PubMed)

Pradeep AR, Kumar MS, Ramachandraprasad MV, Shikha C. Gingival crevicular fluid levels of neopterin in healthy subjects and in patients with different periodontal diseases. J Periodontol. 2007 Oct;78(10):1962-7. doi: 10.1902/jop.2007.070096.

Reference Type RESULT
PMID: 18062118 (View on PubMed)

Ozmeric N, Baydar T, Bodur A, Engin AB, Uraz A, Eren K, Sahin G. Level of neopterin, a marker of immune cell activation in gingival crevicular fluid, saliva, and urine in patients with aggressive periodontitis. J Periodontol. 2002 Jul;73(7):720-5. doi: 10.1902/jop.2002.73.7.720.

Reference Type RESULT
PMID: 12146530 (View on PubMed)

Vrecko K, Staedtler P, Mischak I, Maresch L, Reibnegger G. Periodontitis and concentrations of the cellular immune activation marker neopterin in saliva and urine. Clin Chim Acta. 1997 Dec 10;268(1-2):31-40. doi: 10.1016/s0009-8981(97)00154-x.

Reference Type RESULT
PMID: 9495569 (View on PubMed)

Bakhtadze MG, Margvelashvili VV, Kamkamidze GK. [Interferon-gamma and neopterin in blood serum of patients with chronic periodontitis]. Georgian Med News. 2006 Jan;(130):50-3. Russian.

Reference Type RESULT
PMID: 16510912 (View on PubMed)

Other Identifiers

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suma thesis

Identifier Type: -

Identifier Source: org_study_id

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