Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
NCT ID: NCT05297084
Last Updated: 2022-04-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2021-03-27
2021-12-30
Brief Summary
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It was observed that that Clinical parameters and Il-17 and Il-18 levels are higher before treatment but decreased after treatment which suggests role of these interleukins in pathogenesis of aggressive periodontitis .
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Detailed Description
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Aim of the study:
Objectives were to compare and correlate the clinical parameters and biochemical parameters (Il-17 and Il-18 levels in GCF) of aggressive periodontitis patients (At baseline and after three months of nonsurgical treatment) versus periodontally healthy subjects at baseline.
Subjects and methods:
Populations included in the study:
A total of fifty individuals were enrolled and categorized as; group A that included twenty five aggressive periodontitis patients and group B which included twenty five periodontally healthy controls.
Clinical parameters:
Plaque index (PI) ,gingival index (GI), Probing pocket depth (PPD) and clinical attachment level (CAL) were measured at baseline for both groups and after three months of non surgical periodontal treatment completion for group A.
GCF sampling:
In group A ,the site with deepest probing depth was selected for GCF sampling while for group B , any site was sampled using PerioPaper strips .
Phase I periodontal treatment After baseline GCF sample collection and clinical measurement recordings, group A patients received phase I periodontal treatment.
Analysis of Il-17 and Il-18 levels in GCF:
GCF samples were examined by enzyme-linked immunosorbent assay (ELISA).Procedures were performed according to the directions in the kits.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Aggressive periodontitis
25 young medically free patients with deep periodontal pockets \>5mm
non surgical periodontal therapy
Scaling and root planing
Periodontally healthy individuals
25 young medically free individuals with no periodontal inflammation signs
No interventions assigned to this group
Interventions
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non surgical periodontal therapy
Scaling and root planing
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Subjects with prior use of antibiotics in the last 6 months.
* Smokers.
* Pregnant females.
* Lactating females.
18 Years
30 Years
ALL
Yes
Sponsors
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Future University in Egypt
OTHER
Responsible Party
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Sarah Elkot
Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt.
Principal Investigators
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Sarah M Elkot, Lecturer
Role: PRINCIPAL_INVESTIGATOR
Lecturer of Oral Medicine and Periodontology
Locations
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Faculty of oral and dental medicine,FUE, Cairo,Egypt
Cairo, , Egypt
Countries
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Other Identifiers
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FUE11
Identifier Type: -
Identifier Source: org_study_id
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