Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

NCT ID: NCT05295576

Last Updated: 2022-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-27

Study Completion Date

2021-12-30

Brief Summary

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The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

Detailed Description

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Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls.

Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).

Conditions

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Aggressive Periodontitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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chronic periodontitis

scaling and root planing

non surgical periodontal therapy

Intervention Type PROCEDURE

Scaling and root planing

Periodontally healthy individuals

no treatment

No interventions assigned to this group

Interventions

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non surgical periodontal therapy

Scaling and root planing

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Medically free subjects .
* both genders .
* age range between 30 to 60 years old .

Exclusion Criteria

* Subjects with periodontal surgeries in the last 6 months.
* Subjects with prior use of antibiotics in the last 6 months.
* Smokers.
* Pregnant and lactating females were excluded.
* Lactating females.
Minimum Eligible Age

30 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Future University in Egypt

OTHER

Sponsor Role lead

Responsible Party

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Sarah Elkot

Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sarah M Elkot, Lecturer

Role: PRINCIPAL_INVESTIGATOR

Lecturer of Oral Medicine and Periodontology

Locations

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Future university in Egypt

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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FUE12

Identifier Type: -

Identifier Source: org_study_id

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