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Effect of Pranayama on Periodontal Health

NCT ID: NCT02967861

Last Updated: 2016-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Study Completion Date

2016-07-31

Brief Summary

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The objective of the study was to evaluate the levels of Peroxisome proliferator-activated receptor gamma (PPAR-γ), Nuclear factor-kappa B (NF-kB) and the presence of red complex microorganisms (RCM) such as Treponema denticola (T.d), Porphyromonas gingivalis (P.g) and Tannerella forsythia (T.f) in the subgingival tissues of chronic periodontitis subjects before and after intervention with pranayama as an adjunct to scaling and root planing.

Detailed Description

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Sixty chronic periodontitis subjects were selected out of which 30 subjects (control group) were treated with scaling and root planing (SRP) and 30 subjects (pranayama group) also underwent SRP and pranayama for 3 months. Clinical parameters were recorded and the presence of PPAR-γ, NF-kB and RCM were assessed at baseline and after 3 months

Conditions

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Chronic Periodontitis

Keywords

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chronic periodontitis Nuclear factor-kappa B Pranayama Peroxisome proliferator - activated receptor gamma Red complex microorganisms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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SRP & pranayama (lifestyle modification)

30 chronic periodontitis subjects treated with SRP \& pranayama for 3 months

Group Type ACTIVE_COMPARATOR

Pranayama

Intervention Type BEHAVIORAL

Pranayama is the breathing exercise through the nostrils. It enhances the systemic immunity which in turn enhances the overall defense mechanism of an individual.

Scaling and root planing

30 chronic periodontitis subjects treated with scaling and root planing only

Group Type PLACEBO_COMPARATOR

Scaling and root planing

Intervention Type PROCEDURE

It is a mechanical debridement of dental plaque.

Interventions

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Pranayama

Pranayama is the breathing exercise through the nostrils. It enhances the systemic immunity which in turn enhances the overall defense mechanism of an individual.

Intervention Type BEHAVIORAL

Scaling and root planing

It is a mechanical debridement of dental plaque.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* presence of at least 20 teeth
* Probing pocket depth ≥ 5 mm

Exclusion Criteria

* aggressive periodontitis
* systemic disorders
* pregnant \& lactating females
* smokers \& alcoholics
* immunocompromised individuals
Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Meenakshi Ammal Dental College and Hospital

OTHER

Sponsor Role lead

Responsible Party

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Dr.Jaideep Mahendra

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jaideep Mahendra, MDS, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Meenakshi Ammal Dental College & Hospital

References

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Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-83. doi: 10.1146/annurev.immunol.14.1.649.

Reference Type RESULT
PMID: 8717528 (View on PubMed)

Pilkington K, Kirkwood G, Rampes H, Richardson J. Yoga for depression: the research evidence. J Affect Disord. 2005 Dec;89(1-3):13-24. doi: 10.1016/j.jad.2005.08.013. Epub 2005 Sep 26.

Reference Type RESULT
PMID: 16185770 (View on PubMed)

Other Identifiers

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MAHER-MU-002-IEC/2016

Identifier Type: -

Identifier Source: org_study_id