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Study of the Causal Link Betw...

Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization

Last Updated: 2024-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

220000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-10-01

Study Completion Date

2024-12-01

Brief Summary

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This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

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Detailed Description

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The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Conditions

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Rheumatoid Arthritis Periodontitis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Participants included in the genome-wide association study (GWAS) database.
* Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.