Diagnosis of Periodontal Disease Using Genetic Marker in Saliva

NCT ID: NCT02069574

Last Updated: 2014-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-12-31

Brief Summary

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The purpose of the present study is to identify the novel periodontal disease biomarkers using differentially expressed microRNA in the saliva. The severity of chronic periodontal diseases and the time of pre- and post-treatment are major classification criteria. The obtained data will secure the foundation for the development of a new non-invasive diagnostic methods for early diagnosis \& prognosis prediction of periodontal disease.

Detailed Description

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Conditions

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Chronic Periodontitis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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severe periodontitis group

non-surgical periodontal therapy

Group Type EXPERIMENTAL

non-surgical periodontal therapy

Intervention Type PROCEDURE

Moderate periodontitis group

non-surgical periodontal therapy

Group Type EXPERIMENTAL

non-surgical periodontal therapy

Intervention Type PROCEDURE

healthy control

No treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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non-surgical periodontal therapy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

A. Severe Periodontal Disease

* Patients with chronic severe periodontitis
* Primary treatment of periodontal scaling, subgingival curettage is required, and the general progress of the protocol agreed with the basic periodontal therapy patients.
* subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing

A. Moderate Periodontal Disease

* Patients with chronic moderate periodontitis
* Primary treatment of periodontal scaling, subgingival curettage is required, and the general progress of the protocol agreed with the basic periodontal therapy patients.
* subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing

C. Healthy Control

* Healthy periodontal patients ( more than 20 permanent teeth are present , in all parts of deep periodontal pockets measuring 4mm or less, and height is 2mm or less clinical attachment person)
* subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing

Exclusion Criteria

* Received periodontal treatment within the last six months
* recently taken antibiotics within 3 months if you need a prescription antibiotic prophylaxis
* taking the drug can affect periodontal status for a long period of time
* pregnant or breastfeeding
* In case of oral inflammatory mucosal disease (Lichen planus, etc.)
* A history of alcoholism or drug abuse if
* other special systemic disease (high blood pressure)
* ages under 18
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Su-Hwan Kim

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Su-Hwan Kim, PhD.

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

Locations

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ASAN Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Central Contacts

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Su-Hwan Kim, PhD.

Role: CONTACT

82-2-3010-5797

Facility Contacts

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Su-Hwan Kim, PhD

Role: primary

82-2-3010-5797

Other Identifiers

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2013-0940

Identifier Type: -

Identifier Source: org_study_id

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