Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
81 participants
OBSERVATIONAL
2024-07-25
2024-09-25
Brief Summary
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* Do salivary mitofusin-1 and mitofusin-2 levels of periodontitis patients differ from healthy patients?
* Could salivary mitofusin-1 and mitofusin-2 levels be biomarkers for periodontal disease?
Biochemical analysis will be performed on saliva samples taken at once from gingivitis or periodontitis patients and healthy individuals who apply to the periodontology clinic, at the initial stage of the treatment. There is no ongoing monitoring or second sampling.
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Detailed Description
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Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Healthy
Biochemical analysis of saliva sample
It is the examination of saliva samples taken with biochemical methods. In this way, the substances in its content and the concentration of cytokines are analyzed.
Gingivitis
Biochemical analysis of saliva sample
It is the examination of saliva samples taken with biochemical methods. In this way, the substances in its content and the concentration of cytokines are analyzed.
Periodontitis
Biochemical analysis of saliva sample
It is the examination of saliva samples taken with biochemical methods. In this way, the substances in its content and the concentration of cytokines are analyzed.
Interventions
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Biochemical analysis of saliva sample
It is the examination of saliva samples taken with biochemical methods. In this way, the substances in its content and the concentration of cytokines are analyzed.
Eligibility Criteria
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Inclusion Criteria
* Willing to participate in the study and provide a saliva sample.
* Having a healthy periodontal condition, gingivitis, or periodontitis (Stage 3-4, Grade C).
* Having fasted from any food or drink (except water) for the past 2 hours prior to providing the saliva sample.
* Having refrained from brushing teeth or using mouthwash in the past 2 hours prior to providing the saliva sample.
* Not having any systemic diseases.
* Not currently taking any medications regularly.
Exclusion Criteria
* Having received periodontal treatment within the last 6 months.
* Having fewer than 20 teeth (excluding third molars).
* Having any systemic diseases.
* Not smoking or having quit at least 5 years ago.
18 Years
65 Years
ALL
Yes
Sponsors
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Erzincan University
OTHER
Responsible Party
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Ömer Faruk Okumuş
Assistant Professor
References
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Okumus OF, Kurt N, Kantarci A. Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study. BMC Oral Health. 2025 Oct 6;25(1):1542. doi: 10.1186/s12903-025-06932-0.
Other Identifiers
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EUDF-OKUMUS-004
Identifier Type: -
Identifier Source: org_study_id
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