The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders
NCT ID: NCT02498938
Last Updated: 2016-08-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2015-03-31
2015-12-31
Brief Summary
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Detailed Description
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COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.
SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.
Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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SERPINA1 gene in COPD and periodontitis
patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (\>4mm pocket probing depth)
SERPINA1 gene
2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism
Interventions
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SERPINA1 gene
2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* patients not willing to participate in the study
30 Years
70 Years
ALL
Yes
Sponsors
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Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
OTHER
Responsible Party
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Dr.Sneha Agarwal
P.G student
Principal Investigators
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Dr. Sneha Agarwal, PG(perio)
Role: PRINCIPAL_INVESTIGATOR
Panineeya Mahavidyalaya institute of dental sciences and research centre
Locations
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Dr. Sneha Agarwal PG(periodontics)
Hyderabad, Telangana, India
Countries
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References
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Scott DA, von Ahsen N, Palmer RM, Wilson RF. Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis. J Clin Periodontol. 2002 Dec;29(12):1118-21. doi: 10.1034/j.1600-051x.2002.291212.x.
Travis J, Pike R, Imamura T, Potempa J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S143-6. doi: 10.1164/ajrccm/150.6_Pt_2.S143.
Other Identifiers
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D149206031
Identifier Type: -
Identifier Source: org_study_id
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