Neurokinin A and Matrix Metalloproteinase 9 Levels in Gingival Crevicular Fluid Samples of Teeth With Symptomatic Irreversible Pulpitis With Symptomatic Apical Periodontitis
NCT ID: NCT07289074
Last Updated: 2025-12-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
23 participants
OBSERVATIONAL
2026-02-28
2026-11-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
This study will utilize a comparative cross-sectional design to assess the levels of Neurokinin A (NKA) and Matrix metalloproteinase-9 (MMP-9) in gingival crevicular fluid (GCF) samples from symptomatic and healthy contralateral teeth with normal pulp.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
OTHER
CROSS_SECTIONAL
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Patients diagnosed with symptomatic irreversible pulpitis with symptomatic apical peridontitis
* Gingival crevicular fluid samples will be collected from the symptomatic teeth and from the healthy contalateral teeth with normal pulp to detect the lavel of Neurokinin A (NKA) and Matrix metalloproteinase-9 (MMP-9) in the diseased teeth and compare it with that of the healthy teeth.
* The study will also correlate the level of these biomarkers with the preoperative pain severity using the Numerical Rating Scale (NRS).
Gingival crevicular fluid samples from the symptomatic teeth and the healthy contrlateral teeth
The detection of the inflammatory biomarkers levels in the gingival crevicular fluid of the symptomatic teeth is considered an objective,molecular-based and non invasive method for diagnosis.
The healthy contralateral teeth of tha same patients
* Gingival crevicular fluid samples will be collected from the symptomatic teeth and from the healthy contalateral teeth to detect the lavel of Neurokinin A (NKA) and Matrix metalloproteinase-9 (MMP-9) in the diseased teeth and compare it with that of the healthy contralateral teeth.
* The study will also correlate the level of these biomarkers and the preoperative pain severity using the Numerical Rating Scale (NRS).
Gingival crevicular fluid samples from the symptomatic teeth and the healthy contrlateral teeth
The detection of the inflammatory biomarkers levels in the gingival crevicular fluid of the symptomatic teeth is considered an objective,molecular-based and non invasive method for diagnosis.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Gingival crevicular fluid samples from the symptomatic teeth and the healthy contrlateral teeth
The detection of the inflammatory biomarkers levels in the gingival crevicular fluid of the symptomatic teeth is considered an objective,molecular-based and non invasive method for diagnosis.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* The involved teeth should have healthy periodontal conditions (Normal periodontal pocket depth, No bleeding on Probing and No mobility).
* Patients who have not undergone any previous dental treatments in the involved teeth.
* Signed informed consent.
Exclusion Criteria
* Patients taking medications that can affect the inflammatory markers (e.g., Steroids and Tetracyclins).
* Smokers.
* Individuals with periodontal disease unrelated to apical periodontitis.
* Presence of marginal bone loss.
* Pregnant women.
18 Years
60 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Hadeer Mostafa El Mohamady El Feky
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Hadeer Mostafa El Mohamady El Feky
PhD Candidate at Faculty of Dentistry- Endodontic Department (Cairo univerity)
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Saied M Abdel Aziz, Professor of Endodontics
Role: STUDY_DIRECTOR
Faculy of Dentistry, Cairo university, Egypt
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Faculty of Dentistry, Cairo university
Cairo, Cairo Governorate, Egypt
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Hadeer M El Mohamady El Feky, BDS, MSc, PhD Candidate
Role: CONTACT
Phone: +201029997864
Email: [email protected]
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Hadeer M EL Mohamady EL Feky, BDS, MSc, PhD Candidate
Role: primary
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
Hadeer Mostafa -14422022580639
Identifier Type: -
Identifier Source: org_study_id