Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis

NCT ID: NCT03426241

Last Updated: 2018-02-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-02-10
• Study Completion Date: 2012-12-30

Brief Summary

This study comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the hypothesis of this study was that smoking may interfere with periodontal disease by effecting MMP-2 and MMP-9 expressions.

Detailed Description

Smokers have greater risk for developing periodontal disease and smoking is highly correlated with greater marginal bone loss. Matrix metalloproteinases (MMP) play a major role in periodontal tissue destruction. MMP-2 and MMP-9, called gelatinases, are one of the major MMPs that plays important roles in periodontitis. To date, several studies showed the increased levels of gelatinases in periodontal disease and only a limited number of study investigated the effect of smoking on gelatinases. However, no previous study has directly investigated the possible relationship between smoking and gingival tissue gelatinases expressions (MMP-2 and MMP-9) in chronic periodontitis (CP) patients relative to periodontally healthy subjects.

Therefore this study is conducted to comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the of this study hypothesis was that smoking may interfere with periodontal disease by effecting MMP-2 and MMP-9 expressions.

Conditions

Periodontitis; Smoking

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

smoking chronic periodontitis

no intervention

Intervention Type: OTHER

this is cross-sectional study

non-smoking periodontitis

no intervention

Intervention Type: OTHER

this is cross-sectional study

smoking healthy

no intervention

Intervention Type: OTHER

this is cross-sectional study

non-smoking healthy

no intervention

Intervention Type: OTHER

this is cross-sectional study

Interventions

no intervention

this is cross-sectional study

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• A total of 80 subjects (35 females, 45 males, with an age range of 16-62 years) were included in this study from those patients seeking dental treatment at the Baskent University School of Dentistry between February 2010 and December 2012.

Exclusion Criteria

• Patients with systemic disease;
• pregnant and/or lactating women;
• patients taking any medications that may influence the study.

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 62 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Baskent University

OTHER

Sponsor Role: lead

Responsible Party

Yasemin Sezgin

Clinician in periodontology department

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

BaskentU2

Identifier Type: -

Identifier Source: org_study_id