Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
NCT ID: NCT04583085
Last Updated: 2020-10-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
75 participants
OBSERVATIONAL
2018-11-01
2019-12-31
Brief Summary
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Detailed Description
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Seventy-five participants were selected and grouped into 3 categories; 25 patients diagnosed with chronic periodontitis and coronary artery disease: CP + CAD group; 25 patients diagnosed with chronic periodontitis alone: CP group; and 25 systemically and periodontally healthy controls (HP). Demographic variables, periodontal parameters, cardiac parameters, blood pressure were obtained. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all the three groups. Within CP+CAD group, SP samples of CP+CADa were compared with coronary plaques samples (CP) of CP+CADb while the patient underwent CABG.
Conditions
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Study Design
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OTHER
OTHER
Study Groups
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CP + CHD group
This was further divided into CP + CHDa (Subgingival plaque) and CP + CHDb (Coronary plaque) based on the nature of plaque collected.
No interventions assigned to this group
CP group
25 patients with chronic periodontitis who were systemically healthy were selected
No interventions assigned to this group
HP group
25 patients who were systemically and periodontally healthy, were considered as HP group.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients between the age group of 30-70 years
* Presence of ≥ 15 natural teeth.
Exclusion Criteria
* Under treatment with antibiotics, immunosuppressive drugs such as corticosteroids, within 6 months.
* Pregnant women and female patients were excluded because of the altered oral flora due to hormonal changes
* Smoking and other tobacco usage habits
* Patients who underwent periodontal treatment within 6 months.
30 Years
70 Years
MALE
No
Sponsors
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Meenakshi Ammal Dental College and Hospital
OTHER
Responsible Party
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Dr.Jaideep Mahendra
Professor, Director of PG education
Locations
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Meenakshi Ammal Dental college
Chennai, Tamil Nadu, India
Countries
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Other Identifiers
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MADC/IRB-XXVI/2018/415
Identifier Type: -
Identifier Source: org_study_id
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