Evaluation of Inflammatory Markers and Periodontal Viruses on Periodontitis Patients With CAD
NCT ID: NCT04172870
Last Updated: 2020-02-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
240 participants
OBSERVATIONAL
2018-11-15
2020-12-01
Brief Summary
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Detailed Description
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1. GROUP I: 60 healthy subjects ( No generalised periodontitis and no CAD)
2. GROUP II: 60 generalised periodontitis subjects without CAD
3. GROUP III: 60 CAD subjects without generalised periodontitis
4. GROUP IV: 60 subjects with Generalised periodontitis and CAD
Sub-gingival plaque samples will be collected from the subjects of all the four groups. Coronary artery plaque samples will be collected from the patients who were indicated for coronary artery bypass graft surgery (CABG) among group III and group IV.
The demographic variables , periodontal parameters , cardiac parameters , expression of periodontal viruses and inflammatory biomarkers will be measured in all four groups ,
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Group I
Healthy group ( No generalised periodontitis and no CAD)
Molecular analysis
RT- PCR
Group II
Generalised periodontitis patients without CAD
Molecular analysis
RT- PCR
Group III
CAD patients without generalised periodontitis
Molecular analysis
RT- PCR
Group IV
Generalised periodontitis with CAD
Molecular analysis
RT- PCR
Interventions
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Molecular analysis
RT- PCR
Eligibility Criteria
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Inclusion Criteria
2. Patients with 30 to 65 years of age group
3. Both genders
4. Patients should have minimum of 10 natural teeth.
5. In case of group III and IV patients with coronary heart disease to be included.
Exclusion Criteria
2. Type I and II Diabetes mellitus
3. Sarcoidosis patients.
4. Carcinoma patients.
5. Rheumatic arthritis patients.
6. Tuberculosis patients.
7. Immunosuppressive conditions.
8. Patients with other inflammatory diseases.
30 Years
65 Years
ALL
Yes
Sponsors
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Meenakshi Ammal Dental College and Hospital
OTHER
Responsible Party
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Dr.Jaideep Mahendra
Professor and Director of PG studies
Principal Investigators
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Jaideep Mahendra, PhD
Role: PRINCIPAL_INVESTIGATOR
MeenakshiAmmal Dental College & Hospital
Locations
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MeenakshiAmmal Dental College and Hospital
Chennai, Tamil Nadu, India
Countries
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References
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Gurses KM, Kocyigit D, Yalcin MU, Canpinar H, Oto MA, Ozer N, Tokgozoglu L, Guc D, Aytemir K. Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris. Am J Cardiol. 2015 Dec 1;116(11):1666-71. doi: 10.1016/j.amjcard.2015.08.048. Epub 2015 Sep 11.
Jenny NS, Arnold AM, Kuller LH, Tracy RP, Psaty BM. Associations of pentraxin 3 with cardiovascular disease and all-cause death: the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):594-9. doi: 10.1161/ATVBAHA.108.178947. Epub 2009 Jan 22.
Imbronito AV, Marcelino SL, Grande SR, Nunes FD, Romito GA. Detection of human cytomegalovirus and epstein-barr virus in coronary atherosclerotic tissue. Braz J Microbiol. 2010 Jul;41(3):563-6. doi: 10.1590/S1517-83822010000300004. Epub 2010 Sep 1.
Other Identifiers
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FLL/IRC/01/2017
Identifier Type: OTHER
Identifier Source: secondary_id
MADC/IRB/2017/260
Identifier Type: -
Identifier Source: org_study_id
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